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| Name | Class |
|---|---|
| Malaysian Society of Anaesthesiologists | OTHER |
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This study aims to determine the optimal dose of alfentanil in suppressing the airway reflexes during supreme LMA removal in anaesthetized adult.
The removal of LMA may be associated with coughing, biting, agitation and airway complication such as laryngospasm. Thus it is advisable to remove the LMA when the patient is breathing spontaneously and when the airway reflexes are still depressed. A number of techniques have been used to prevent this adverse emergence phenomenon, such as removing the tube while the patient is in deep plane of anaesthesia or administration of local anaesthetic and intravenous opioids
The administration of intravenous opioids before emergence may be useful for preventing cough, agitation and hemodynamic response. Alfentanyl is proven to suppress cough and agitation during the endotracheal tube emergence. However, its use in suppressing cough in LMA patient has not been evaluated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| alfentanil | Experimental | patient will received a dose of alfentanil in which the dose of alfentanil is determined by response of previously tested patient using Dixon up and down methods |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| alfentanil | Drug | Alfentanil is administered intravenously at the end of surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Optimal dose of alfentanil for successful LMA removal in spontaneously breathing anaesthetized adults | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patient with airway complication | after administration of alfentanil and within 1 min of LMA removal |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Lee Chew Kiok, MBBS | Department of Anaesthesiogy, UMMC. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Malaya Medical Centre | Kuala Lumpur | 59100 | Malaysia |
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| ID | Term |
|---|---|
| D015760 | Alfentanil |
| ID | Term |
|---|---|
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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