Vitamin D Supplementation in Adult Crohn's Disease

Vitamin D and Immunomodulation: Effects in Crohn's Disease

The purpose of this study is to determine whether vitamin D supplementation is effective in the prevention of relapse in Crohn's disease.

Inclusion Criteria:

• All patients must fulfill the clinical criteria for diagnosis of Crohn's disease.
• Subjects must have inactive CD as defined by CDAI < 150
• CRP </=10 mg/L.

Exclusion Criteria:

• Pregnant and lactating women.
• Known hypersensitivity to vitamin D.
• Hypercalcaemia
• Current supplemental intake of vitamin D3 >800 IU/D.
• Diagnosis of any of the following: active tuberculosis, sarcoidosis, hyperparathyroidism, pseudohyperparathyroidism, renal failure or malignancy, active TB, sarcoidosis, lymphoma.
• Participation in a concurrent clinical trial.