Study of the Natural History of FFR Guided Percutaneous Coronary Intervention

A Multicenter, Prospective Cohort to Evaluate the Natural History of FFR Guided Percutaneous Coronary Intervention

About 20,000 patients with FFR (Fractional Flow Reserve) will be enrolled and evaluated for the natural history of coronary lesions at 2 years clinical and imaging follow-up.

This is a multicenter, prospective cohort. About 20,000 patients with FFR will be enrolled at multi centres in Korea.

Inclusion Criteria:

• Age 35 years and older
• FFR measurement on one and more coronary artery stenosis
• Willing and able to provide informed, written consent

Exclusion Criteria:

• Stenosis with TIMI<3 flow
• Graft vessel
• Ejection fraction < 30%
• Angiographic evidence of extreme tortuosity or calcified coronary vessels
• Suspected coronary spasm even after sufficient nitrate injected
• Life expectancy <2 year
• Planned cardiac surgery or planned major non cardiac surgery
• Woman who are breastfeeding, pregnant or planning to become pregnant during the course of the study

Imaging study specific exclusion criteria

• visually-estimated angiographic reference segment diameter of <2.75mm or >4.0mm
• Inappropriate for IVUS/VH/OCT procedures : inability for imaging wire or catheter to pass through the tight stenosis, severe calcification, angulation