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The primary purpose of this study is to estimate the relative bioavailability and food effect of a PF-03882845 tablet as compared to a suspension formulation used in previous clinical studies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Suspension/fasted | Experimental |
| |
| Tablet/fasted | Experimental |
| |
| Tablet/fed | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PF-03882845 | Drug | 25 mg of PF-03882845 suspension (75% SDD) will be given as a single oral dose under fasted condition |
|
| Measure | Description | Time Frame |
|---|---|---|
| PF-03882845 PK: Cmax, AUCinf, AUClast, Tmax, t1/2, as data permit. | Post dose is measured at 24, 48 and 96 hours after dose. | predose and post each dose (24, 48 and 96 hour timepoints) |
| Safety: Safety labs, vital signs, ECGs, physical examinations and adverse event monitoring. | 45 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Pfizer CT.gov Call Center | Pfizer | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Pfizer Investigational Site | Brussels | 1070 | Belgium |
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| Label | URL |
|---|---|
| To obtain contact information for a study center near you, click here. | View source |
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| PF-03882845 | Drug | 25 mg PF-03882845 Tablet (75% SDD) will be given as a single oral dose under fasted condition |
|
| PF-03882845 | Drug | 25 mg PF-03882845 Tablet (75% SDD) will be given as a single oral dose under fed condition |
|
| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| C552104 | (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo(g)indazole-7-carboxylic acid |
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