This study will investigate whether early exercise in critically ill patients will decrease inflammatory markers, increase pro-inflammatory markers and prevent loss of muscle mass.

This study will investigate the effects of an early targeted rehabilitation program on inflammatory markers and muscle mass in patients with sepsis syndromes in intensive care.

The Primary Hypothesis is that an early targeted rehabilitation ICU patients with sepsis syndromes over 7 days will Prevent loss of lean muscle mass by within 7 days of recruitment to the study. Decrease pro-inflammatory and increase anti-inflammatory cytokines within 7 days of recruitment to the study.

Inclusion Criteria:

• Systemic inflammatory response syndrome with a proven or suspected infectious etiology.
• 18 years and over
• Relatives willing to give consent
• Admitted to intensive care and likely to remain ventilated for > 48 hours

Exclusion Criteria:

• Patients with septic shock unresponsive to maximal treatment or who are moribund or have an expected mortality within 48 hours
• Head injuries
• Burn injury
• Multiple lower limb fractures