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The purpose of this study is to provide an opportunity for patients with malignancies or bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Total Body Irradiation/VP16 | Other | Acute Leukemias, Myelodysplastic syndromes |
|
| Cytoxan/Total Body Irradiation | Other | Chronic Leukemias, Bone Marrow Failure States, Lymphomas, Hodgkin's Disease |
|
| Busulfan/Cytoxan | Other | Acute Leukemia, Myelodysplastic syndromes, Chronic Leukemias, Bone Marrow Failure states |
|
| BEAM (BCNU, etoposide, Ara-C, melphalan) | Other | Lymphomas, Hodgkin's Disease |
|
| Total Lymphoid Irradiation | Other | For patients with Multiple Myeloma, or prior autologous transplantation, or age in excess of 55 |
|
| Cladribine/Melphalan | Other |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Allogeneic transplantation | Procedure | Allogeneic transplantation with matched unrelated donors |
|
| Measure | Description | Time Frame |
|---|---|---|
| Bone Marrow and Peripheral Blood Chimerism | Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing. | 30 days post-transplant |
| Bone Marrow and Peripheral Blood Chimerism | Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing. | 100 days post-transplant |
| Bone Marrow and Peripheral Blood Chimerism | Percent of donor and host cells in peripheral blood and bone marrow will be measured by short tandem repeat (STR) testing and/or standard cytogenetic testing. | 365 days post-transplant |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeffrey W. Andrey, MD | Scripps Clinic Medical Group | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Scripps Green Hospital | La Jolla | California | 92037 | United States |
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For patients with Multiple Myeloma, or prior autologous transplantation, or age in excess of 55
|
| FLAG (fludarabine, Ara-C, G-CSF) | Other | For patients undergoing a second allogeneic transplant |
|
|
| ID | Term |
|---|---|
| D000741 | Anemia, Aplastic |
| D006457 | Hemoglobinuria, Paroxysmal |
| D015470 | Leukemia, Myeloid, Acute |
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| D009190 | Myelodysplastic Syndromes |
| D015464 | Leukemia, Myelogenous, Chronic, BCR-ABL Positive |
| D006689 | Hodgkin Disease |
| D008228 | Lymphoma, Non-Hodgkin |
| D009101 | Multiple Myeloma |
| D015451 | Leukemia, Lymphocytic, Chronic, B-Cell |
| ID | Term |
|---|---|
| D000740 | Anemia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D000080983 | Bone Marrow Failure Disorders |
| D001855 | Bone Marrow Diseases |
| D000743 | Anemia, Hemolytic |
| D007951 | Leukemia, Myeloid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D007945 | Leukemia, Lymphoid |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |
| D009196 | Myeloproliferative Disorders |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008223 | Lymphoma |
| D054219 | Neoplasms, Plasma Cell |
| D020141 | Hemostatic Disorders |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010265 | Paraproteinemias |
| D001796 | Blood Protein Disorders |
| D006474 | Hemorrhagic Disorders |
| D015448 | Leukemia, B-Cell |
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| ID | Term |
|---|---|
| D014184 | Transplantation, Homologous |
| ID | Term |
|---|---|
| D014180 | Transplantation |
| D013514 | Surgical Procedures, Operative |
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