Unrelated Donor Stem Cell Transplantation

Allogeneic Hematopoietic Progenitor Cell Transplantation From Unrelated Donors

The purpose of this study is to provide an opportunity for patients with malignancies or bone marrow failure states who lack a suitable sibling donor to undergo allogeneic hematopoietic progenitor cell transplantation using cells from unrelated individuals or cord blood registries.

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Inclusion Criteria:

• > 18 years of Age
• < 70 years
• ECOG performance status 0, 1 or 2
• Left Ventricular Ejection Fraction > 30%
• Creatinine clearance > 40ml/min
• Transaminases < 2X normal
• Total bilirubin < 2X normal
• HIV seronegativity
• Weight < 70kg for cord blood transplantation
• Ability to cover the cost of the transplant, necessary medications, and transportation/housing.
• Caregiver must be available while outpatient

Exclusion Criteria:

• Greater than one antigen mismatch at HLA-A, B, C or DR plus one allele mismatch at HLA-A, B, C or DR