Genotypic and Phenotypic Correlates of Resistance to Aspirin

Genotypic and Phenotypic Correlates of Resistance to Anti-platelet Actions of Aspirin in an At-risk Patient Population and in the General Population

The study seeks to identify genomic markers associated with aspirin resistance.

Not desired

Inclusion Criteria:

• Volunteers 40 to 80 years old willing to sign consent and take 81 mg of aspirin for 7 - 10 days and return for laboratory testing.

Exclusion Criteria:

• Patient requiring more than 81 mg aspirin daily

• Known GI bleeding attributed to ASA

• Active peptic ulcer disease or history within the last year

• Known aspirin allergy

• Current use of:

  • warfarin,
  • heparin,
  • NSAIDs (except aspirin),
  • clopidogrel,
  • dipyridamole,
  • fish-oil/omega 3 supplements,

• Women of childbearing potential who are pregnant, planning to become pregnant or nursing.