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The purpose of this study was to compare the effectiveness of nifedipine versus indomethacin as tocolytic for the treatment of preterm labour with short cervix (< 2.5cms).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nifedipine | Experimental | 108 patients will receive nifedipine as tocolytic for 48 hours. |
|
| Indomethacin | Experimental | 108 patients will receive indomethacin as tocolytic for 48 hours. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nifedipine | Drug | Nifedipine: 20 mg as a single dose upon admission and then 10 mg vo every 8 hours for 48 hours. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of preterm birth (before 48 hours, allowing use of corticosteroids). | 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Reduction of preterm labour (before 35 weeks). | 48 months | |
| Adverse effects | To determine the frequency of maternal adverse effects related to the use of both drugs (nifedipine and indomethacin). These include the development of any type of rash, nausea, weakness/hypotension, headache, dyspepsy or bleeding disorders of any kind. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jorge Espinosa, Resident | Contact | bobbyone-79@hotmail.com | ||
| Osvaldo Reyes, MD | Contact | oreyespanama@yahoo.es |
| Name | Affiliation | Role |
|---|---|---|
| Jorge Espinosa, Resident | Saint Thomas Hospital, Panama | Principal Investigator |
| Osvaldo Reyes, MD | Saint Thomas Hospital, Panama | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Saint Thomas Hospital | Panama City | Provincia de Panamá | Panama |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35947046 | Derived | Wilson A, Hodgetts-Morton VA, Marson EJ, Markland AD, Larkai E, Papadopoulou A, Coomarasamy A, Tobias A, Chou D, Oladapo OT, Price MJ, Morris K, Gallos ID. Tocolytics for delaying preterm birth: a network meta-analysis (0924). Cochrane Database Syst Rev. 2022 Aug 10;8(8):CD014978. doi: 10.1002/14651858.CD014978.pub2. |
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| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D009543 | Nifedipine |
| D007213 | Indomethacin |
| ID | Term |
|---|---|
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| Indomethacin | Drug | Indomethacin: 50 mg vo as a single dose upon admission and then 25 mg vo every 6 hours for 48 hours. |
|
| 48 months |
| D007211 |
| Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |