31P-MRS and Huntington Disease

31Phosphorus-Magnetic Resonance Spectroscopy and Huntington Disease

The purpose of this study is to identify and quantify a brain energy deficit in Huntington patients, using 31P-RMN spectroscopy.

Inclusion Criteria:

• 5<UHDRS<50
• Age>18 years
• Ability to undergo MR scanning
• Covered by french social security

Exclusion Criteria:

• Evidence of psychiatric disorder
• Attendant neurological disorder
• Contraindications to MRI (claustrophobia, metallic or material implants)
• Severe head injury
• Unable to understand the protocol
• Pregnancy
• Failure to give informed consent
• Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent)
• Unwillingness to be informed in case of abnormal MRI