A Study of RO6807952 in Patients With Diabetes Mellitus Type 2

A Randomized, Placebo-Controlled, Sequential, Multiple-Ascending Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MAR701/RO6807952 in Type 2 Diabetic Patients

This randomized, placebo-controlled, multiple ascending dose study will evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of RO6807952. Patients will receive multiple weekly subcutaneous doses of RO6870952. The anticipated time on study treatment is 8 weeks.

Inclusion Criteria:

• Adult patients, 18 to 70 years of age, inclusive
• Diagnosis of type 2 diabetes >/=3 months and </=10 years prior to screening
• Fasting plasma glucose >/=110 mg/dL and </=240 mg/dL
• Patients on a stable dose of metformin for at least 2 months prior to screening
• Hemoglobin HbA1c >/=6.5% and </=10.5%
• Body mass index >/=25 kg/m2 and </=42 kg/m2
• Systolic blood pressure <155 mmHg and diastolic blood pressure <95 mmHg

Exclusion Criteria:

• Patients with type 1 diabetes
• History of significant renal and hepatic diseases
• History of metabolic acidosis and diabetic gastroparesis
• History of pancreatitis
• History of coagulation disorders or unexplained excessive bleeding
• History of clinically significant cardiovascular disease or severe symptomatic hypoglycemia within 6 months of screening