Effect of Resveratrol on Age-related Insulin Resistance and Inflammation in Humans

Effect of Resveratrol on Age-related Insulin Resistance and Inflammation in Humans

Resveratrol is a natural polyphenol (a compound containing a phenol functional group) that can be found in many plants. The purpose of this research is to study the effects of resveratrol on the action of insulin (a hormone produced in the body by the pancreas that regulates the amount of sugar in the blood), fat accumulation, and inflammation in the body.

Participants will meet with the study team to discuss dietary recommendations. Each participant will be instructed to follow a standardized diet plan and to avoid vigorous exercise before beginning the study. Participants will be given a 28 day supply of resveratrol capsules (Two 500 mg capsules taken twice a day). A comprehensive study of whole-body insulin action called a pancreatic clamp will be done and small samples of fat and muscle will be taken before and after the administration of resveratrol.

Inclusion Criteria:

• BMI: 26-35
• Non-smoker
• Normal screening labs (CMC, chemistry, LFTs PT/PTT)
• No CAD
• Good IV access

Exclusion Criteria:

• High cholesterol

• <4 week history of participation in another drug trial

• Severe hypertension

• Heart disease

• Liver disease of liver abnormalities

• Cerebrovascular disease, i.e. stroke

• CVD

• Seizures

• Bleeding disorders

• Muscle disease

• Cancer

• HIV

• Hepatitis (all types)

• Mentally disabled persons

• Pregnant women

• Allergies to Novocaine, Lidocaine, Benzocaine

• Subjects on the following medications:

  • Anticoagulant and antiplatelet drugs
  • Anti-epileptic drugs
  • Mexiletene
  • Quinidine
  • Cyclosporine
  • Tacrolimus
  • HIV protease inhibitors