A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers

A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers

Esomeprazole plus aspirin compared with esomeprazole alone for the treatment of aspirin-related peptic ulcers.

The aims of this study are to compare esomeprazole plus aspirin with esomeprazole alone in the treatment of aspirin-related ulcers.

Patients with aspirin-related peptic ulcers are randomized to receive esomeprazole (40 mg/day) plus aspirin (100 mg/day) or esomeprazole (40 mg/day) alone for 8 weeks. Follow-up endoscopy was carried out at the end of the eighth week. The primary end point was the healing of peptic ulcers.

Inclusion Criteria:

• aspirin users who have a peptic ulcer confirmed by endoscopy

Exclusion Criteria:

• serious medical illness (including cardiovascular events within 6 months before endoscopy)
• acute gastrointestinal bleeding
• a history of gastric or duodenal surgery
• allergic to the study drugs
• require long-term treatment with non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs), antiplatelet agents, or anticoagulant agents
• pregnancy