The Relationship of Hemoglobin A1c and Diabetic Wound Healing

The Relationship of Hemoglobin A1c and Diabetic Wound Healing

The purpose of this study is to investigate the relationship of hemoglobin A1c in diabetic wound healing. Additionally, a comparison of two wound dressings, AmeriGel® (Amerx Health Care Corp., Clearwater, FL) and Bacitracin, with and without vitamin C supplementation, will be done to evaluate impact on time to wound closure.

This is a prospective randomized controlled study evaluating the relationship of hemoglobin A1c in diabetic wound healing. Length of time for wound closure will be compared using four treatment options.

Inclusion Criteria:

• >18 years of age
• Diabetic (Type I and Type II)
• Ulceration of the foot at least one centimeter in width/length
• Ulceration at least 0.2 centimeters in depth

Exclusion Criteria:

• Ulceration width/length > 7.5 centimeters
• Wound depth > 1.25 centimeters
• Purulent, excessive drainage and/or other signs of infection (i.e. erythema, edema, warmth)
• Inability to provide informed consent
• Inability to swallow pills (vitamin C supplement)
• Patients with concurrent renal problems
• Patients with medication contraindications to Vitamin C and/or topical wound dressings