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The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental Knee Pain | Experimental | Experimental knee pain induced by injections of 1 ml hypertonic saline in to the infrapatellar fat pad |
|
| Control | Active Comparator | non-painful injections of isotonic saline into the infrapatellar fatpad. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Experimental knee pain | Other | Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad |
|
| Measure | Description | Time Frame |
|---|---|---|
| Isokinetic knee muscle strength | At baseline and after 8 weeks of exercise |
| Measure | Description | Time Frame |
|---|---|---|
| One-leg chair rise | At baseline and after 8 weeks of exercise |
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Inclusion Criteria:
Exclusion Criteria:
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 21905254 | Derived | Sorensen TJ, Langberg H, Hodges PW, Bliddal H, Henriksen M. Experimental knee joint pain during strength training and muscle strength gain in healthy subjects: a randomized controlled trial. Arthritis Care Res (Hoboken). 2012 Jan;64(1):108-16. doi: 10.1002/acr.20618. |
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| Non-painful control injections | Other | Injection of isotonic saline into the infrapatellar fat pad |
|