Study to Investigate the Effect of Formoterol vs Salmeterol on Small Airways Physiological Parameters in COPD Patients

A Single-centre, Double-blind, Double-dummy, Randomised, Crossover Study to Investigate the Effect of Formoterol HFA-pMDI Versus Salmeterol HFA-pMDI on Small Airways Physiological Parameters in COPD Patients

This is a crossover Study to investigate the effect of Formoterol versus Salmeterol on small airways physiological parameters in COPD patients.

A Single-centre, Double-blind, Double-dummy, Randomised, Crossover Study to investigate the effect of Formoterol HFA-pMDI versus Salmeterol HFA-pMDI on small airways physiological parameters in COPD patients.

Inclusion Criteria:

• Patients with a clinical diagnosis of COPD
• Post bronchodilator FEV1 between 30% and 80% predicted values at screening
• Post-bronchodilator FEV1/FVC < 0.7

Exclusion Criteria:

• Positive FEV1 reversibility test: FEV1 change greater than 200 mL and 12%
• History of another medical condition contraindicating participation in the study
• Clinical evidence of heart failure