Clearance Rate of Peritoneal Fluid After Full Conditioning Pneumoperitoneum

Clearance Rate of Peritoneal Fluid Assessed by Post-operative Ultrasound Decreases After Full Conditioning Pneumoperitoneum

Measurement of residual peritoneal fluid after laparoscopic surgery

Primary endpoints

• to evaluate whether the clearance rate of peritoneal fluid is exponential or linear over time. (absorption rate expected for Adept ~30-60 ml/h)
• to evaluate the role of the mesothelial barrier in this clearance rate.

Knowing that diffusion to and from peritoneal fluid decreases with increasing molecular weight (MW), our hypothesis is that clearance rate will decrease following peritoneal conditioning. Indeed a decreased mesothelial trauma (either through hypoxia or through denudation) and retraction will expose less the basal membrane

Secondary endpoints:

-To confirm the decrease in post-operative pain as measured by VAS-score and inflammation as measured by CRP and leucocytosis with the full conditioning of the pneumoperitoneum.

Inclusion Criteria:

• Women planned to undergo a total or subtotal laparoscopic hysterectomy and having signed the informed consent.
• No limitation in body mass index or uterine size is made.

Exclusion Criteria:

• pregnancy
• immunodeficiency
• refuse or unable to sign informed consent
• chronic disease (i.e. COPD, Crohn, cardiac…)
• known allergy for Adept©