The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors.

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors. To do so, the metabolic risk factor response to an n-e PUFA supplementation will be compared in carriers and non-carriers of polymorphism within genes acting as fatty acids sensors.

Inclusion Criteria:

• healthy men and women aged between 18 to 50 years;
• having a BMI between 25 and 40kg/m2;
• plasma triglycerides levels <4.0 mmol/L;
• non-smokers;
• free of any thyroid or metabolic disorders requiring treatment such as diabetes, hypertension, severe dyslipidemia, and coronary heart disease.

Exclusion Criteria:

• subjects taking medication for hyperlipidemia, hypertension, diabetes or taking anticoagulant or n-3 PUFA supplementation;
• having a taste aversion for fish, fish allergy or regular alcohol drinker;
• body mass index > 40kg/m2;
• pregnant or nursing women.