This study aims to determine whether or not gadoxetate disodium (Eovist) enhanced magnetic resonance imaging (MRI) has a higher sensitivity for detecting hepatocellular carcinoma (Liver Cancer) comparison to multi-detector computed tomography (CT).

Inclusion Criteria:

• Alpha-feto protein > 400 ng / mL or
• prior ultrasound with mass suspicious for hepatic malignancy or.
• clinical risk of hepatocellular carcinoma or
• prior multi-detector CT with mass suspicious for possible hepatocellular carcinoma

Exclusion Criteria:

• Glomerulo-filtration rate < 50 mL/ min/1.73 m2 based on a creatinine measurement within three months of the MR study
• Previous diagnosis of hepatic malignancy
• Any conditions that would discount the ability to have an MRI scan

75 patients of the San Francisco VA Medical Center with suspected HCC identified on contrast-enhanced multi-detector CT, or on ultrasound and referred to contrast-enhanced multi-detector CT.