Reverse Phototherapy With Super Light-emitting Diode(Super-LED) for Hyperbilirubinemia in Term and Late Preterm Infants

Efficacy of Reverse Phototherapy With Super Light-emitting Diode(Super-led) in Term and Late Preterm Infants:Randomized and Controlled Clinical Trial

The aim of this study is to compare the efficacy of super-LED reverse phototherapy with the fluorescent reverse phototherapy in term and late preterm newborns.

This is a randomized controlled clinical trial with hospitalized infants in the Professor Fernando Figueira Medicine Institute(IMIP), who require phototherapy as an indication of the medical team. Following the sample calculation, 144 patients will be randomized according to gestational age (350/7-376/7 or 380/7-416/7 weeks) to receive super-LED reverse phototherapy or fluorescent reverse phototherapy with spectral irradiance of 8-12 microwatts/cm2/nm.The bilirubin will be determined by micromethod with bilirubinometer, after blood collection in heparinized capillary until bilirubin reaches level that indicates suspension of therapy.

Inclusion Criteria:

• Newborns in the maternity Professor Fernando Figueira Medicine Institute(IMIP)
• Gestational age between 350/7 and 416/7 weeks
• Birth weight greater than 2200g
• Absence of congenital malformations
• indication of phototherapy after 48 hours of life
• Terms of consent signed by parent or guardian

Exclusion Criteria:

• Total Bilirubin level indicative of phototherapy intensive or exchange transfusion
• RH incompatibility hemolytic disease
• Mother's refusal to continue to participate in the study
• Unavailability of the two types of phototherapy equipment for randomization
• Mother or newborn who received phenobarbital