Comparison of the Incidence of Dyskinesia in Parkinson's... | NCT01338662

NCT01338662

Protocol Section

Identification Module

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Status Module

Oversight Module

Description Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Group A-1		study enroll number 3n+1 (N=0,1,2...) initial treatment- amantadine add levodopa when the patient become to need further treatment.
Group A-2		study enroll number 3n+2 (N=0,1,2...) initial treatment: amantadine add dopamine agonist when the patient become to need further treatment.
Group B		study enroll number 3n+3 (N=0,1,2...) initial treatment: dopamine agonist add levodopa when the patient become to need further treatment. but cannot use amantadine

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
dyskinesia onset	observe duration of onset of dyskinesia from initial treatment observe until 10 years	up to 10 years from the start of durg (Amantadine or dopaimine agonsit)

Secondary Outcomes

Measure	Description	Time Frame
UPDRS, severity of dyskinesia between groups	observe duration of onset of dyskinesia from initial treatment observe until 10 years compare the UPDRS and severity of dyskinesia between groups	observe duration of onset of dyskinesia from initial treatment

Eligibility Module

Contacts/Locations Module

Name	Role	Phone	Extension	Email
Beom S Jeon, MD, PhD	Contact	82-2-2072-2876		brain@snu.ac.kr
Young Eun Kim, MD	Contact	82-2-2072-1219		yeksl99@hanmail.net

Name	Affiliation	Role
Beom S Jeon, MD, PhD	Seoul National University Hospital	Study Chair

Facility	Status	City	State	ZIP	Country	Contacts
Beom S Jeon	Recruiting	Seoul			South Korea

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
10816186	Background	Rascol O, Brooks DJ, Korczyn AD, De Deyn PP, Clarke CE, Lang AE. A five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa. N Engl J Med. 2000 May 18;342(20):1484-91. doi: 10.1056/NEJM200005183422004.
8089666	Background	Montastruc JL, Rascol O, Senard JM, Rascol A. A randomised controlled study comparing bromocriptine to which levodopa was later added, with levodopa alone in previously untreated patients with Parkinson's disease: a five year follow up. J Neurol Neurosurg Psychiatry. 1994 Sep;57(9):1034-8. doi: 10.1136/jnnp.57.9.1034.

Condition Browse Module

ID	Term
D020734	Parkinsonian Disorders
D001480	Basal Ganglia Diseases
D001927	Brain Diseases
D002493	Central Nervous System Diseases