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This observational study will assess the efficacy and safety of RoActemra/Actemra (Tocilizumab) in smoking versus non-smoking patients with rheumatoid arthritis. Data from patients treated in routine clinical practice with intravenous RoActemra/Actemra will be collected for 12 months each.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in disease activity score (DAS 28) | 12 months | |
| Treatment patterns (frequency/dosage) and demographics of patients treated with RoActemra/Actemra in routine clinical practice | 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Safety: Incidence of adverse events | 36 months | |
| Quality of life: Health assessment questionnaire Disease Index (HAQ-DI), Functional Assessment of Chronic Illness Therapy- Fatigue (FACIT-Fatigue) questionnaire | 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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Rheumatoid arthritis patients on treatment with RoActemra/Actemra
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Trials | Hoffmann-La Roche | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ålesund | 6017 | Norway | ||||
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| Rate of patients achieving remission (DAS <2.6) | 36 months |
| Change in blood lipids | 12 months |
| Clinical response (DAS 28/blood chemistry/QoL) with or without methotrexate | 36 months |
| Bergen |
| 5053 |
| Norway |
| Drammen | 3004 | Norway |
| Gjettum | 1346 | Norway |
| Kristiansand | 4604 | Norway |
| Levanger | 7600 | Norway |
| Lillehammer | 2609 | Norway |
| Skien | 3722 | Norway |
| Trondheim | 7030 | Norway |
| Eskilstuna | 631 88 | Sweden |
| Falun | 79182 | Sweden |
| Farsta | 541 85 | Sweden |
| Gothenburg | 413 45 | Sweden |
| Kalmar | 39185 | Sweden |
| Karlstad | 65185 | Sweden |
| Kristianstad | 29185 | Sweden |
| Linköping | 58185 | Sweden |
| Luleå | 97180 | Sweden |
| Malmö | 205 02 | Sweden |
| Oskarström | 31392 | Sweden |
| Örebro | 70185 | Sweden |
| Östersund | 831 02 | Sweden |
| Simrishamn | 272 81 | Sweden |
| Skövde | 54185 | Sweden |
| Stockholm | 171 76 | Sweden |
| Stockholm | 205 02 | Sweden |
| Uddevalla | 45180 | Sweden |
| Uppsala | 75185 | Sweden |
| Västerås | 72189 | Sweden |
| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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