Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer

Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer

The purpose of this study is to determine proportion of patients presented a search allelic imbalance of expression of genes BRCA 1 and 2 in population with hereditary breast and/or ovarian cancer risk and negative for deletion mutation BRCA 1 and 2 genes

Inclusion Criteria:

For patients

• Women with breast cancer and / or ovarian cancer meet criteria suggestive of a hereditary predisposition
• Deleterious mutation of BRCA1 and BRCA2 sought and not highlighted
• Age ≥ 18 years
• Agreeing to participate in the study (a collection of signed informed consent)

For control population

• Women with no history of breast and / or ovarian cancer and no family history of breast and / or ovarian cancer among family members on the 1st and 2nd degree before age 50 for breast cancer and before 60 years for ovarian cancer
• Agreeing to participate in the study (a collection of signed informed consent)

Exclusion Criteria:

For patients:

• Patients with a known deleterious mutation in BRCA1 and BRCA2
• Patients do not meet criteria suggestive of a hereditary predisposition
• Persons deprived of liberty or under guardianship (including guardianship)

For control population:

• Males
• Personal or family history of breast and / or ovarian cancer (breast or ovarian cancer in their family experienced 1st and 2nd degree before age 50 for breast cancer before age 60 for cancer ovarian)
• Persons deprived of liberty or under guardianship (including guardianship)