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| Name | Class |
|---|---|
| Novo Nordisk A/S | INDUSTRY |
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The purpose of this study is to investigate how Glucagon-Like Peptide 1 (GLP-1) affects kidney function in healthy young men. The hypothesis is that GLP-1 induces a positive effect on kidney hemodynamics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GLP-1 | Active Comparator |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Human GLP-1 (7-36) amide | Biological | 2 hour IV infusion, 1,5pmol/min/kg. |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Glomerular Filtration Rate | Every 20 minutes for 6 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jeppe Skov, MD | University of Aarhus | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinisk Institut, Afd. MEA, Aarhus Sygehus, NBG | Aarhus C | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23463656 | Derived | Skov J, Dejgaard A, Frokiaer J, Holst JJ, Jonassen T, Rittig S, Christiansen JS. Glucagon-like peptide-1 (GLP-1): effect on kidney hemodynamics and renin-angiotensin-aldosterone system in healthy men. J Clin Endocrinol Metab. 2013 Apr;98(4):E664-71. doi: 10.1210/jc.2012-3855. Epub 2013 Mar 5. |
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| ID | Term |
|---|---|
| D000577 | Amides |
| ID | Term |
|---|---|
| D009930 | Organic Chemicals |
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| Isotone NaCl |
| Biological |
2 hours IV infusion. |
|