This is a phase 1, open-label pharmacokinetic study where up to 40 subjects with advanced solid tumors (up to 6-10 with normal renal function and up to 18-30 with varying degrees of renal dysfunction) will receive weekly doses of AMG 386 intravenously. The primary objective is to evaluate the pharmacokinetics (PK) of single agent AMG 386 in subjects with various degrees of renal function. Once the AMG 386 PK characterization is complete in the first 5 weeks of the study, all subjects will be allowed to continue to receive AMG 386 weekly only or subjects in group 1, 2 or 3 can opt to receive AMG 386 weekly in combination with paclitaxel until disease progression, unacceptable toxicity or withdrawal of consent.

Inclusion Criteria:

• Men or women ≥ 18 years of age
• Must have a pathologically documented, and definitively diagnosed, advanced solid tumor that is refractory to standard treatment, or for which no curative therapy is available, or for subjects who refuse standard therapy
• Evaluable OR measurable disease by RECIST 1.1 criteria
• Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1
• Life expectancy of > 3 months, in the opinion of and as documented by the investigator
• Subject or subject's legally acceptable representative has provided informed consent

Exclusion Criteria:

• Subjects with gastric cancer or any malignancy with purely squamous cell histology
• Known history of primary central nervous system (CNS) tumors or CNS metastases
• Myocardial infarction within 1 year before study day 1, unstable or uncontrolled disease/condition related to or affecting cardiac function (eg, unstable angina, congestive heart failure, New York Heart Association > class II, uncontrolled hypertension [diastolic > 90 mmHg; systolic > 150 mmHg in repeated measurements])
• History of stroke, arterial or venous thrombosis, or pulmonary embolism within 1 year before study day 1
• Active grade 2 or greater peripheral vascular disease or peripheral edema
• History of interstitial lung disease (eg, pneumonitis or pulmonary fibrosis)
• Non-healing wound, ulcer (including gastrointestinal) or fracture
• Known positive test for human immunodeficiency virus infection, or active hepatitis B or hepatitis C infection
• Major surgery within 4 weeks before study day 1
• Absolute neutrophils count (ANC) < 1.0 x 10^9/L; or platelet count < 100 x 10^9/L; or hemoglobin < 9 g/dL; or PTT / aPTT > 1.5 x institutional upper limit of normal (ULN) ); or INR > 1.5
• Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 2.5 x ULN (> 5.0 x ULN if liver metastases present)
• Alkaline phosphatase > 2.5 x ULN (> 5.0 x ULN if attributable to liver or bone metastasis)
• Total bilirubin > 1.5 x ULN
• Other investigational procedures during the study
• Previous anti-cancer therapy or investigational agent within 4 weeks prior to study day 1
• Anticoagulation therapy within 4 weeks of study day 1 and while on study (except low dose warfarin (≤ 2 mg/kg) for prophylaxis against central venous catheter thrombosis)
• Men and women of reproductive potential, unwilling to practice a highly effective method of birth control for the duration of the study and an additional 6 months after the last dose of AMG 386. Highly effective methods of birth control include sexual abstinence (men, women); vasectomy or a condom with spermicide (men) in combination with barrier methods, hormonal birth control or IUD (women).
• Women who are lactating/breastfeeding.
• Women with a positive pregnancy test.