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Resveratrol is associated with a plethora of physiological effects in humans, including modulation of cerebral blood flow, despite apparently poor bioavailability. This study investigated whether the physiological effects of resveratrol could be affected when co-supplemented with piperine, an alkaloid which may be able to enhance the bioavailability of resveratrol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 250mg trans- resveratrol | Experimental |
| |
| 250mg trans-resveratrol with 20mg piperine | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trans- resveratrol | Dietary Supplement | All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner. |
| Measure | Description | Time Frame |
|---|---|---|
| Modulation of levels of total haemoglobin | 80 minutes following treatment administration | |
| Modulation of levels of deoxygenated haemoglobin | 80 minutes following treatment administration | |
| Modulation of levels of oxygenated haemoglobin | 80 minutes following treatment administration |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants displaying significant modulation of cognitive performance | Cognitive performance was assessed at baseline and then again 40 minutes post-treatment to assess if any changes had taken place. | 40-80 minutes post dose |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Emma L Wightman | Northumbria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brain performance and nutrition research centre, Northumbria university | Newcastle upon Tyne | Tyne and Wear | NE1 8ST | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24804871 | Derived | Wightman EL, Reay JL, Haskell CF, Williamson G, Dew TP, Kennedy DO. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr. 2014 Jul 28;112(2):203-13. doi: 10.1017/S0007114514000737. Epub 2014 May 7. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Jul 10, 2012 | |
| Reset | Aug 15, 2012 | |
| Release | Aug 22, 2012 | |
| Reset | Sep 24, 2012 | |
| Release | Sep 25, 2012 | |
| Reset | Oct 26, 2012 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Jul 10, 2012 | Aug 15, 2012 | |||
| Aug 22, 2012 |
| ID | Term |
|---|---|
| D000077185 | Resveratrol |
| D012822 | Silicon Dioxide |
| ID | Term |
|---|---|
| D000081225 | Stilbestrols |
| D013267 | Stilbenes |
| D001597 | Benzylidene Compounds |
| D001555 | Benzene Derivatives |
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|
| Placebo (silica) | Other | All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner. |
|
| Sep 24, 2012 |
| Sep 25, 2012 | Oct 26, 2012 |
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D059808 | Polyphenols |
| D010636 | Phenols |
| D008903 | Minerals |
| D007287 | Inorganic Chemicals |
| D010087 | Oxides |
| D017601 | Oxygen Compounds |
| D017655 | Silicon Compounds |