A Study to Compare Two Different Tablet Formulations of AZD8931 in Healthy Males and Females

A Phase I, Randomised, Open-label, Cross-over, Single-centre Study in Healthy Male and Non-fertile Female Volunteers to Determine the Relative Bioavailability of the Phase II Wet Granulation Tablet Formulation Compared to the Phase II/III Roller Compacted Tablet Formulation of AZD8931

A study to compare two different tablet formulations of AZD8931 in healthy males and females.

Inclusion Criteria:

• Male or female subjects aged 18 to 55 years
• Females must have a negative pregnancy test at screening and on admission to the unit, must not be lactating and must be of non-child bearing potential
• Body mass index between 19 and 30 kg/m2 and weight at least 50 kg and no more than 100 kg
• Male subjects must be willing to use barrier methods of contraception
• Be willing and able to comply with study procedures, restrictions and requirements

Exclusion Criteria:

• History of any clinically significant disease or disorder
• Any clinically significant abnormalities at screening
• Use of any prescribed or non-prescribed medication within 2 weeks
• Receipt of another NCE or participation in any other clinical trial within 3 months
• Subjects who have previously received AZD8931