Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2010-021239-15 | EudraCT Number |
Not provided
Not provided
Study will not be initiated as planned.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study will provide patients who have completed the AIN457 Phase II and Phase III clinical trials in non-infectious uveitis continued access to treatment with AIN457 while collecting safety data and information on long term clinical use of treatment with AIN457.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AIN457 300mg s.c every 2 weeks | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AIN457 | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| Participants with adverse events as a measure of safety and tolerability | up to 36 months | |
| Proportion of patients achieving the criteria for clinically inactive posterior segment uveitis | up to 36 months | |
| Mean time to achieve the criteria for clinically inactive posterior segment uveitis | up to 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of patients experiencing clinically active posterior segment uveitis in patients discontinuing AIN457 treatment | up to 36 months | |
| Time to recurrence of clinically active posterior segment uveitis after discontinuation of AIN457 treatment | up to 36 months |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Other protocol-defined inclusion/exclusion criteria may apply
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Novartis Pharmaceuticals | Novartis Pharmaceuticals | Study Director |
Not provided
Not provided
| ID | Term |
|---|---|
| D014605 | Uveitis |
| D015867 | Uveitis, Intermediate |
| D015864 | Panuveitis |
| D015866 | Uveitis, Posterior |
| ID | Term |
|---|---|
| D014603 | Uveal Diseases |
| D005128 | Eye Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| C555450 | secukinumab |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Time to resolution of a recurrence of clinically active posterior segment uveitis in patients discontinuing AIN457 and treated only with the reinitiation of AIN457 | up to 36 months |