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The aim of the study is a medico-economic evaluation to estimate a cost differential between three modalities of Intensity-Modulated Radiation Therapy for cancers of the prostate, cervix and anal canal with pelvic lymph node irradiation : treatment with helical Tomotherapy and dynamic arc therapy using two different technologies: RapidArc or VMAT.
- Treatment by IMRT: Radiotherapy Modalities. All volumes will receive a base dose of 45 Gy in 25 fractions or 46 Gy in 23 fractions, followed by additional irradiation doses that vary depending on the type of tumor. The treatment will be carried out in one or more phases.
this will take place at 3 months, 6 months, 12 months, and 18 months after the end of irradiation for cervical and anal canal cancers, and extended to 24, 30, and 36 months, then at 4 and 5 years for prostate cancers, with an evaluation of the treatment's effectiveness and tolerance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prostate | Other | Patients with prostate cancer |
|
| Anal canal | Other | Patients with anal canal |
|
| Cervix cancer | Other | Patients with Cervix cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| IMRT using Rapid Arc - prostate cancer | Radiation | IMRT using Dynamic arc therapy by Rapid Arc technique for patients with prostate cancer |
|
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stéphane SUPIOT, MD, PhD | Institut de Cancérologie de l'Ouest | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Européen Georges Pompidou | Paris | Paris | 75015 | France | ||
| Institut Sainte Catherine |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Mar 15, 2013 |
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| IMRT using Rapid Arc - Anal canal cancer | Radiation | IMRT using Dynamic arc therapy by Rapid Arc technique for patients with Anal canal cancer |
|
| IMRT using Rapid Arc - Cervix cancer | Radiation | IMRT using Dynamic arc therapy by Rapid Arc technique for patients with cervix cancer |
|
| IMRT with HT - prostate cancer | Radiation | IMRT using helical tomotherapy (HT) technique with prostate cancer |
|
| IMRT with HT - Anal canal cancer | Radiation | IMRT using helical tomotherapy (HT) technique with Anal canal cancer |
|
| IMRT with HT - cervix cancer | Radiation | IMRT using helical tomotherapy (HT) technique with cervix cancer |
|
| IMRT with VMAT - prostate cancer | Radiation | IMRT using Volumetric Modulated Arc Therapy (VMAT) with prostate cancer |
|
| IMRT with VMAT - Anal canal cancer | Radiation | IMRT using Volumetric Modulated Arc Therapy (VMAT) with Anal canal cancer |
|
| IMRT with VMAT - cervix cancer | Radiation | IMRT using Volumetric Modulated Arc Therapy (VMAT) with cervix cancer |
|
| Avignon |
| 84000 |
| France |
| Institut Bergonié | Bordeaux | 33000 | France |
| Centre Léon Bérard | Lyon | 69373 | France |
| Institut Paoli Calmette | Marseille | 13273 | France |
| Assistance publique des Hôpitaux de Marseille | Marseille | 13385 | France |
| Hôpital Clinique Claude Bernard | Metz | 57 070 | France |
| Groupe Oncorad | Montauban | 82000 | France |
| Centre Val d'Aurelle | Montpellier | 34298 | France |
| Centre Alexis Vautrin | Nancy | 54500 | France |
| Institut Curie | Paris | 75013 | France |
| Institut de cancérologie de l'ouest | Saint-Herblain | 44800 | France |
| Centre Paul Strauss | Strasbourg | 67065 | France |
| Institut Claudius Regaud | Toulouse | 31000 | France |
| Groupe Oncorad | Toulouse | 31300 | France |
| Jan 9, 2026 |
| Prot_SAP_000.pdf |
| ID | Term |
|---|---|
| D011471 | Prostatic Neoplasms |
| D002583 | Uterine Cervical Neoplasms |
| ID | Term |
|---|---|
| D005834 | Genital Neoplasms, Male |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D011469 | Prostatic Diseases |
| D052801 | Male Urogenital Diseases |
| D014594 | Uterine Neoplasms |
| D005833 | Genital Neoplasms, Female |
| D002577 | Uterine Cervical Diseases |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D050397 | Radiotherapy, Intensity-Modulated |
| ID | Term |
|---|---|
| D020266 | Radiotherapy, Conformal |
| D011881 | Radiotherapy, Computer-Assisted |
| D011878 | Radiotherapy |
| D013812 | Therapeutics |
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