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| ID | Type | Description | Link |
|---|---|---|---|
| 2010-A00858-31 | Other Identifier | ANSM |
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Our primary objective is to evaluate the relevance of the early determination of Candida infection status among non-neutropenic patients hospitalized over 48 hours in ICUs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The study population | The target population includes patients in ICUs at the Nîmes and Montpellier University hospitals. This is a population of non-neutropenic patients (polynuclear neutrophils > 500/mm3) at risk of developing invasive candidiasis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tests for candidiasis | Biological | Tests include (1) anti-candida antibody ELISA kit; (2) candida antigen ELISA kit; (3) detection of circulating Candida DNA via SYBR Breen qPCR Master mix; (4) colonization index based on mycological examination of five out of the following: urine, oral swab, bronchial aspirate, anal swab, swab of a central venous line, gastric liquid. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of positive Candidiasis tests | Number of tests (score of 0 to 4) positive for Candida. Tests include (1) anti-candida antibody ELISA kit; (2) candida antigen ELISA kit; (3) detection of ciruclating Candida DNA via SYBR Breen qPCR Master mix; (4) colonization index based on mycological examination of five out of the following: urine, oral swab, bronchial aspirate, anal swab, swab of a central venous line, gastric liquid. | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Number of positive Candidiasis tests | Number of tests (score of 0 to 4) positive for Candida. Tests include (1) anti-candida antibody ELISA kit; (2) candida antigen ELISA kit; (3) detection of ciruclating Candida DNA via SYBR Breen qPCR Master mix; (4) colonization index based on mycological examination of five out of the following: urine, oral swab, bronchial aspirate, anal swab, swab of a central venous line, gastric liquid. |
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Inclusion Criteria:
Exclusion Criteria:
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The target population includes patients in ICUs at the Nîmes and Montpellier University hospitals. This is a population of non-neutropenic patients (polynuclear neutrophils > 500/mm3) at risk of developing invasive candidiasis.
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| Name | Affiliation | Role |
|---|---|---|
| Laurence Lachaud, MD | Centre Hospitalier Universitaire de Nīmes | Study Director |
| Nathalie Bourgeois, MD | Centre Hospitalier Universitaire de Nīmes | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Nîmes | Nîmes | Gard | 30029 | France | ||
| CHU de Montpellier |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33923333 | Result | Larcher R, Platon L, Amalric M, Brunot V, Besnard N, Benomar R, Daubin D, Ceballos P, Rispail P, Lachaud L, Bourgeois N, Klouche K. Emerging Invasive Fungal Infections in Critically Ill Patients: Incidence, Outcomes and Prognosis Factors, a Case-Control Study. J Fungi (Basel). 2021 Apr 24;7(5):330. doi: 10.3390/jof7050330. |
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| ID | Term |
|---|---|
| D002177 | Candidiasis |
| ID | Term |
|---|---|
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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Serum sample
|
| 2 days |
| Patient leaves ICU unit, yes/no | 1 month |
| Patient passes away in ICU unit, yes/no | 1 month |
| Patient has been prescribed an antifungal treatment in the past month, yes/no | 1 month |
| Montpellier |
| 34090 |
| France |