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| Name | Class |
|---|---|
| Norwegian Cancer Society | OTHER |
| University Hospital, Akershus | OTHER |
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This is a randomized, controlled trial on frail elderly patients (aged 65+) with colorectal cancer. The patients will be randomized into two groups. The control group will receive standard surgical treatment. The intervention group will in addition go through a preoperative comprehensive geriatric assessment. The assessment will include evaluation of co-morbidity and medication, social status, nutritional status, cognition, depression and physical performance. This assessment will form basis of an individualized perioperative intervention.
The main aim of the study is to see if the number of postoperative complications in this group can be reduced by a perioperative geriatric intervention. A study of inflammation markers in serum will also be performed, with focus on identifying potential biological frailty markers.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Geriatric intervention | Experimental |
| |
| Control | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Geriatric intervention | Other | A comprehensive geriatric assessment (CGA), focusing on co-morbidity, medication, cognitive status, depression, nutritional status and physical status is performed. The intervention is individualized according to the results of the CGA. |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative complications | 30 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Reoperation | Number of patients in need of any operation within thirty days after the operation for colorectal cancer. | 30 days after surgery |
| Readmission | Number of patients being readmitted to hospital within 30 days after operation for colorectal surgery. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Torgeir B Wyller, Dr.med | Geriatric dept., Oslo University hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept of gastrointestinal surgery, Oslo University Hospital | Oslo | 0424 | Norway |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| 30 days after surgery |
| Length of hospital stay | 30 days after surgery |
| Survival | 3 months after surgery |
| Quality of life | 3 months after surgery |
| Living at home or in institution | Number of patients living at home, with or without formal help, and number of patients living in nursing homes 3 months after surgery. | 3 months after surgery |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |