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To investigate the efficacy and safety of PARIET twice daily (b.i.d.) in patients with Proton Pump Inhibitor-resistant reflux esophagitis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rabeprazole Sodium |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| rabeprazole sodium | Drug | Doses of 10 mg or 20 mg twice daily may be administered orally to reflux esophagitis patients for a further 8 weeks when proton pump inhibitor treatment is ineffective. However, a dose of 20 mg twice daily should only be administered to patients with severe mucosa injury. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of subjects with improvement based on health related Quality of Life (QOL) questionnaire | Check at predose, 4, 8, 16 and 32 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Number of subjects with improvement in symptoms of GERD | Check at predose, 4, 8, 16 and 32 weeks | |
| Endoscopic healing rate | 8 weeks | |
| Adverse events |
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Inclusion criteria;
-Proton pump inhibitor-resistant reflux esophagitis. (Patients who have mucosal breaks (erosions, ulcers) on endoscopy)
Exclusion criteria;
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Hospitals and Clinics in Japan
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| Name | Affiliation | Role |
|---|---|---|
| Yoshinori Furuhata | Drug Fostering and Evolution Coordination Department, Corporate Regulatory Compliance, Safety and Quality Assurance Headquarters, Eisai Co., Ltd. | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aisai | Aichi-ken | Japan | ||||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28502925 | Result | Kinoshita Y, Hongo M, Kusano M, Furuhata Y, Miyagishi H, Ikeuchi S; RPZ Study Group. Therapeutic Response to Twice-daily Rabeprazole on Health-related Quality of Life and Symptoms in Patients with Refractory Reflux Esophagitis: A Multicenter Observational Study. Intern Med. 2017;56(10):1131-1139. doi: 10.2169/internalmedicine.56.7896. Epub 2017 May 15. |
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|
| Every 4-8 weeks |
| Anjo |
| Aichi-ken |
| Japan |
| Gamagōri | Aichi-ken | Japan |
| Ichinomiya | Aichi-ken | Japan |
| Inuyama | Aichi-ken | Japan |
| Kariya | Aichi-ken | Japan |
| Kasugai | Aichi-ken | Japan |
| Nagoya | Aichi-ken | Japan |
| Okazaki | Aichi-ken | Japan |
| Owariasahi | Aichi-ken | Japan |
| Tokoname | Aichi-ken | Japan |
| Toyota | Aichi-ken | Japan |
| Tōkai | Aichi-ken | Japan |
| Tsushima | Aichi-ken | Japan |
| Daisen | Akita | Japan |
| Yokote | Akita | Japan |
| Yurihonjō | Akita | Japan |
| Goshogawara | Aomori | Japan |
| Hachinohe | Aomori | Japan |
| Hirosaki | Aomori | Japan |
| Kitatsugaru | Aomori | Japan |
| Mutsu | Aomori | Japan |
| Sannohe | Aomori | Japan |
| Towada | Aomori | Japan |
| Asahi | Chiba | Japan |
| Choshi | Chiba | Japan |
| Funabashi | Chiba | Japan |
| Ichihara | Chiba | Japan |
| Ichikawa | Chiba | Japan |
| Kashiwa | Chiba | Japan |
| Katori-shi | Chiba | Japan |
| Matsudo | Chiba | Japan |
| Mobara | Chiba | Japan |
| Narashino | Chiba | Japan |
| Noda | Chiba | Japan |
| Imabari | Ehime | Japan |
| Kitauwa | Ehime | Japan |
| Matsuyama | Ehime | Japan |
| Niihama | Ehime | Japan |
| Ōzu | Ehime | Japan |
| Saijō | Ehime | Japan |
| Uwajima | Ehime | Japan |
| Mikatakaminaka | Fukui | Japan |
| Ono | Fukui | Japan |
| Sabae | Fukui | Japan |
| Sakai | Fukui | Japan |
| Asakura | Fukuoka | Japan |
| Buzen | Fukuoka | Japan |
| Chikushi | Fukuoka | Japan |
| Chikushino-shi | Fukuoka | Japan |
| Kasuga | Fukuoka | Japan |
| Kitakyushu | Fukuoka | Japan |
| Kurume | Fukuoka | Japan |
| Miyama | Fukuoka | Japan |
| Munakata | Fukuoka | Japan |
| Nōgata | Fukuoka | Japan |
| Omuta | Fukuoka | Japan |
| Ōkawa | Fukuoka | Japan |
| Tagawa | Fukuoka | Japan |
| Tsuiki | Fukuoka | Japan |
| Wakasugi | Fukuoka | Japan |
| Yame | Fukuoka | Japan |
| Iwaki | Fukushima | Japan |
| Kōriyama | Fukushima | Japan |
| Shirakawa | Fukushima | Japan |
| Sōma | Fukushima | Japan |
| Yama | Fukushima | Japan |
| Hashima | Gifu | Japan |
| Kakamigahara | Gifu | Japan |
| Minokamo | Gifu | Japan |
| Mizunami | Gifu | Japan |
| Ōgaki | Gifu | Japan |
| Sekimachi | Gifu | Japan |
| Tajimi | Gifu | Japan |
| Takayama | Gifu | Japan |
| Agatsuma | Gunma | Japan |
| Kiryū | Gunma | Japan |
| Maebashi | Gunma | Japan |
| Midori | Gunma | Japan |
| Ōta | Gunma | Japan |
| Takasaki | Gunma | Japan |
| Aki | Hiroshima | Japan |
| Fukuyama | Hiroshima | Japan |
| Higashihiroshima | Hiroshima | Japan |
| Kure | Hiroshima | Japan |
| Mihara | Hiroshima | Japan |
| Miyoshi | Hiroshima | Japan |
| Onomichi | Hiroshima | Japan |
| Takehara | Hiroshima | Japan |
| Abashiri | Hokkaido | Japan |
| Abuta | Hokkaido | Japan |
| Asahikawa | Hokkaido | Japan |
| Date | Hokkaido | Japan |
| Ebetsu | Hokkaido | Japan |
| Eniwa | Hokkaido | Japan |
| Fukagawa | Hokkaido | Japan |
| Furano | Hokkaido | Japan |
| Hakodate | Hokkaido | Japan |
| Hokuto | Hokkaido | Japan |
| Ishikari | Hokkaido | Japan |
| Kamiiso | Hokkaido | Japan |
| Kasai | Hokkaido | Japan |
| Kato | Hokkaido | Japan |
| Kayabe | Hokkaido | Japan |
| Kitami | Hokkaido | Japan |
| Kushiro | Hokkaido | Japan |
| Muroran | Hokkaido | Japan |
| Nakagawa | Hokkaido | Japan |
| Obihiro | Hokkaido | Japan |
| Otaru | Hokkaido | Japan |
| Sapporo | Hokkaido | Japan |
| Shibetsu | Hokkaido | Japan |
| Suttsu | Hokkaido | Japan |
| Tomakomai | Hokkaido | Japan |
| Yoichi | Hokkaido | Japan |
| Aioi | Hyōgo | Japan |
| Akashi | Hyōgo | Japan |
| Ako | Hyōgo | Japan |
| Amagasaki | Hyōgo | Japan |
| Ashiya | Hyōgo | Japan |
| Awaji | Hyōgo | Japan |
| Himeji | Hyōgo | Japan |
| Itami | Hyōgo | Japan |
| Kakogawa | Hyōgo | Japan |
| Kobe | Hyōgo | Japan |
| Miki | Hyōgo | Japan |
| Nishinomiya | Hyōgo | Japan |
| Ono | Hyōgo | Japan |
| Sanda | Hyōgo | Japan |
| Sasayama | Hyōgo | Japan |
| Sumoto | Hyōgo | Japan |
| Takarazuka | Hyōgo | Japan |
| Tamba | Hyōgo | Japan |
| Bandō | Ibaraki | Japan |
| Hitachi | Ibaraki | Japan |
| Hitachiota | Ibaraki | Japan |
| Hokota | Ibaraki | Japan |
| Ishioka | Ibaraki | Japan |
| Itako | Ibaraki | Japan |
| Jōsō | Ibaraki | Japan |
| Kitaibaraki | Ibaraki | Japan |
| Koga | Ibaraki | Japan |
| Mito | Ibaraki | Japan |
| Moriya | Ibaraki | Japan |
| Naka | Ibaraki | Japan |
| Ryūgasaki | Ibaraki | Japan |
| Shimo-tsuma | Ibaraki | Japan |
| Tsukuba | Ibaraki | Japan |
| Ushiku | Ibaraki | Japan |
| Hakui | Ishikawa-ken | Japan |
| Hakusan | Ishikawa-ken | Japan |
| Kahoku | Ishikawa-ken | Japan |
| Kanazawa | Ishikawa-ken | Japan |
| Nomi | Ishikawa-ken | Japan |
| Hanamaki | Iwate | Japan |
| Ichinoseki | Iwate | Japan |
| Morioka | Iwate | Japan |
| Ōshū | Iwate | Japan |
| Tōno | Iwate | Japan |
| Kan’onjichō | Kagawa-ken | Japan |
| Marugame | Kagawa-ken | Japan |
| Mitoyo | Kagawa-ken | Japan |
| Takamatsu | Kagawa-ken | Japan |
| Aira | Kagoshima-ken | Japan |
| Ichikikushikino | Kagoshima-ken | Japan |
| Isa | Kagoshima-ken | Japan |
| Izumi | Kagoshima-ken | Japan |
| Kanoya | Kagoshima-ken | Japan |
| Kirishima | Kagoshima-ken | Japan |
| Kumage | Kagoshima-ken | Japan |
| Sendai | Kagoshima-ken | Japan |
| Ashigarashimo | Kanagawa | Japan |
| Atsugi | Kanagawa | Japan |
| Chigasaki | Kanagawa | Japan |
| Fujisawa | Kanagawa | Japan |
| Hadano | Kanagawa | Japan |
| Hiratsuka | Kanagawa | Japan |
| Isehara | Kanagawa | Japan |
| Kamakura | Kanagawa | Japan |
| Kawasaki | Kanagawa | Japan |
| Minamiashigara | Kanagawa | Japan |
| Naka | Kanagawa | Japan |
| Odawara | Kanagawa | Japan |
| Sagamihara | Kanagawa | Japan |
| Yokohama | Kanagawa | Japan |
| Yokosuka | Kanagawa | Japan |
| Zama | Kanagawa | Japan |
| Aso | Kumamoto | Japan |
| Hitoyoshi | Kumamoto | Japan |
| Isshōchi | Kumamoto | Japan |
| Kamimashiki | Kumamoto | Japan |
| Kōshi | Kumamoto | Japan |
| Yatsushiro | Kumamoto | Japan |
| Fukuchiyama | Kyoto | Japan |
| Kameoka | Kyoto | Japan |
| Kyōtango | Kyoto | Japan |
| Maizuru | Kyoto | Japan |
| Mukō | Kyoto | Japan |
| Nantan | Kyoto | Japan |
| Yosa | Kyoto | Japan |
| Iga | Mie-ken | Japan |
| Ise | Mie-ken | Japan |
| Kameyama | Mie-ken | Japan |
| Kitamuro | Mie-ken | Japan |
| Kuwana | Mie-ken | Japan |
| Matsusaka | Mie-ken | Japan |
| Suzuka | Mie-ken | Japan |
| Tsu | Mie-ken | Japan |
| Yokkaichi | Mie-ken | Japan |
| Ōsaki | Miyagi | Japan |
| Sendai | Miyagi | Japan |
| Shiroishi | Miyagi | Japan |
| Toda | Miyagi | Japan |
| Tome | Miyagi | Japan |
| Ebino | Miyazaki | Japan |
| Hyūga | Miyazaki | Japan |
| Koyu | Miyazaki | Japan |
| Kushima | Miyazaki | Japan |
| Miyakonojō | Miyazaki | Japan |
| Nobeoka | Miyazaki | Japan |
| Ina | Nagano | Japan |
| Kamiina | Nagano | Japan |
| Kiso | Nagano | Japan |
| Komagane | Nagano | Japan |
| Matsumoto | Nagano | Japan |
| Nakano | Nagano | Japan |
| Saku | Nagano | Japan |
| Ueda | Nagano | Japan |
| Isahaya | Nagasaki | Japan |
| Sasebo | Nagasaki | Japan |
| Unzen | Nagasaki | Japan |
| Gojō | Nara | Japan |
| Ikoma | Nara | Japan |
| Kashihara | Nara | Japan |
| Kitakatsuragi | Nara | Japan |
| Ōuda-yamaguchi | Nara | Japan |
| Sakurai | Nara | Japan |
| Tenri | Nara | Japan |
| Yamatokōriyama | Nara | Japan |
| Yamatotakada | Nara | Japan |
| Jōetsu | Niigata | Japan |
| Kashiwazaki | Niigata | Japan |
| Minamiuonuma | Niigata | Japan |
| Mitsuke | Niigata | Japan |
| Nagaoka | Niigata | Japan |
| Sado | Niigata | Japan |
| Shibata | Niigata | Japan |
| Tōkamachi | Niigata | Japan |
| Kunisaki | Oita Prefecture | Japan |
| Nakatsu | Oita Prefecture | Japan |
| Taketa | Oita Prefecture | Japan |
| Usa | Oita Prefecture | Japan |
| Yufu | Oita Prefecture | Japan |
| Akaiwa | Okayama-ken | Japan |
| Asakuchi | Okayama-ken | Japan |
| Bizen | Okayama-ken | Japan |
| Kurashiki | Okayama-ken | Japan |
| Niimi | Okayama-ken | Japan |
| Tsukubo | Okayama-ken | Japan |
| Tsuyama | Okayama-ken | Japan |
| Itoman | Okinawa | Japan |
| Nago | Okinawa | Japan |
| Nakagami | Okinawa | Japan |
| Tomigusuku | Okinawa | Japan |
| Urasoe | Okinawa | Japan |
| Daitō | Osaka | Japan |
| Fujiidera | Osaka | Japan |
| Higashiosaka | Osaka | Japan |
| Hirakata | Osaka | Japan |
| Ibaraki | Osaka | Japan |
| Izumi | Osaka | Japan |
| Izumiōtsu | Osaka | Japan |
| Izumisano | Osaka | Japan |
| Kadoma | Osaka | Japan |
| Katano | Osaka | Japan |
| Kishiwada | Osaka | Japan |
| Matsubara | Osaka | Japan |
| Minamikawachi | Osaka | Japan |
| Mino | Osaka | Japan |
| Moriguchi | Osaka | Japan |
| Neyagawa | Osaka | Japan |
| Sakai | Osaka | Japan |
| Sayama | Osaka | Japan |
| Sennan | Osaka | Japan |
| Settsu | Osaka | Japan |
| Suita | Osaka | Japan |
| Takaishi | Osaka | Japan |
| Takatsuki | Osaka | Japan |
| Tondabayashi | Osaka | Japan |
| Toyonaka | Osaka | Japan |
| Yao | Osaka | Japan |
| Imari | Saga-ken | Japan |
| Kanzaki | Saga-ken | Japan |
| Ogi | Saga-ken | Japan |
| Takeo | Saga-ken | Japan |
| Taku | Saga-ken | Japan |
| Tosu | Saga-ken | Japan |
| Ageo | Saitama | Japan |
| Chichibu | Saitama | Japan |
| Fujimi | Saitama | Japan |
| Fukaya | Saitama | Japan |
| Hannō | Saitama | Japan |
| Hidaka | Saitama | Japan |
| Kasukabe | Saitama | Japan |
| Kawagoe | Saitama | Japan |
| Kawaguchi | Saitama | Japan |
| Kazo | Saitama | Japan |
| Kitaadachi | Saitama | Japan |
| Koshigaya | Saitama | Japan |
| Kukichūō | Saitama | Japan |
| Sayama | Saitama | Japan |
| Toda | Saitama | Japan |
| Tokorozawa | Saitama | Japan |
| Warabi | Saitama | Japan |
| Kōka | Shiga | Japan |
| Kusatsu | Shiga | Japan |
| Moriyama | Shiga | Japan |
| Nagahama | Shiga | Japan |
| Ōtsu | Shiga | Japan |
| Rittō | Shiga | Japan |
| Izumo | Shimane | Japan |
| Matsue | Shimane | Japan |
| Yasugi | Shimane | Japan |
| Fuji | Shizuoka | Japan |
| Fujieda | Shizuoka | Japan |
| Fujinomiya | Shizuoka | Japan |
| Fukuroi | Shizuoka | Japan |
| Hamamatsu | Shizuoka | Japan |
| Itō | Shizuoka | Japan |
| Iwata | Shizuoka | Japan |
| Kikugawa | Shizuoka | Japan |
| Mishima | Shizuoka | Japan |
| Numazu | Shizuoka | Japan |
| Shimada | Shizuoka | Japan |
| Shimoda | Shizuoka | Japan |
| Susono | Shizuoka | Japan |
| Yaizu | Shizuoka | Japan |
| Mooka | Tochigi | Japan |
| Nikkō | Tochigi | Japan |
| Sano | Tochigi | Japan |
| Shimotsuga | Tochigi | Japan |
| Utsunomiya | Tochigi | Japan |
| Anan | Tokushima | Japan |
| Awa | Tokushima | Japan |
| Myozai | Tokushima | Japan |
| Narutochō-mitsuishi | Tokushima | Japan |
| Okuno | Tokushima | Japan |
| Adachi City | Tokyo | Japan |
| Akiruno | Tokyo | Japan |
| Akishima | Tokyo | Japan |
| Bunkyo | Tokyo | Japan |
| Chiyoda City | Tokyo | Japan |
| Chūō | Tokyo | Japan |
| Edogawa City | Tokyo | Japan |
| Fuchū | Tokyo | Japan |
| Hachiōji | Tokyo | Japan |
| Higashimurayama | Tokyo | Japan |
| Higashiyamato | Tokyo | Japan |
| Hino | Tokyo | Japan |
| Inagi | Tokyo | Japan |
| Katsushika-ku | Tokyo | Japan |
| Kita-ku | Tokyo | Japan |
| Kodaira | Tokyo | Japan |
| Koganei | Tokyo | Japan |
| Koto | Tokyo | Japan |
| Machida | Tokyo | Japan |
| Meguro City | Tokyo | Japan |
| Minato | Tokyo | Japan |
| Mitaka | Tokyo | Japan |
| Nakano City | Tokyo | Japan |
| Nerima City | Tokyo | Japan |
| Nishitōkyō | Tokyo | Japan |
| Ōme | Tokyo | Japan |
| Ōta-ku | Tokyo | Japan |
| Setagaya City | Tokyo | Japan |
| Shibuya City | Tokyo | Japan |
| Shinagawa | Tokyo | Japan |
| Shinjuku | Tokyo | Japan |
| Suginami | Tokyo | Japan |
| Sumida City | Tokyo | Japan |
| tabashi City | Tokyo | Japan |
| Tachikawa | Tokyo | Japan |
| Toshima City | Tokyo | Japan |
| Kurayoshi | Tottori | Japan |
| Sakaiminato | Tottori | Japan |
| Imizu | Toyama | Japan |
| Kurobe-shi | Toyama | Japan |
| Nakaniikawa | Toyama | Japan |
| Namerikawa | Toyama | Japan |
| Nanto | Toyama | Japan |
| Takaoka | Toyama | Japan |
| Tonami | Toyama | Japan |
| Gobō | Wakayama | Japan |
| Higashimuro | Wakayama | Japan |
| Iwade | Wakayama | Japan |
| Kainan | Wakayama | Japan |
| Nishimuro | Wakayama | Japan |
| Tanabe | Wakayama | Japan |
| Higashiokitama | Yamagata | Japan |
| Kaminoyama | Yamagata | Japan |
| Sakata | Yamagata | Japan |
| Hagi | Yamaguchi | Japan |
| Hikari | Yamaguchi | Japan |
| Iwakuni | Yamaguchi | Japan |
| Sanyōonoda | Yamaguchi | Japan |
| Shimonoseki | Yamaguchi | Japan |
| Ube | Yamaguchi | Japan |
| Yanai | Yamaguchi | Japan |
| Chūō | Yamanashi | Japan |
| Fuefuki | Yamanashi | Japan |
| Kofu | Yamanashi | Japan |
| Kōshū | Yamanashi | Japan |
| Minami-Alps | Yamanashi | Japan |
| Minamikoma | Yamanashi | Japan |
| Tsuru | Yamanashi | Japan |
| Aichi | Japan |
| Akita | Japan |
| Aomori | Japan |
| Chiba | Japan |
| Fukui | Japan |
| Fukuoka | Japan |
| Fukushima | Japan |
| Gifu | Japan |
| Hiroshima | Japan |
| Kagoshima | Japan |
| Kochi | Japan |
| Kumamoto | Japan |
| Kyoto | Japan |
| Mie | Japan |
| Miyazaki | Japan |
| Nagano | Japan |
| Nagasaki | Japan |
| Nara | Japan |
| Niigata | Japan |
| Okayama | Japan |
| Osaka | Japan |
| Ōita | Japan |
| Saga | Japan |
| Saitama | Japan |
| Shizuoka | Japan |
| Tochigi | Japan |
| Tokushima | Japan |
| Tottori | Japan |
| Toyama | Japan |
| Wakayama | Japan |
| Yamagata | Japan |
| Yamanashi | Japan |
| ID | Term |
|---|---|
| D004942 | Esophagitis, Peptic |
| ID | Term |
|---|---|
| D004941 | Esophagitis |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D005759 | Gastroenteritis |
| D010437 | Peptic Ulcer |
| D004378 | Duodenal Diseases |
| D007410 | Intestinal Diseases |
| D013272 | Stomach Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D064750 | Rabeprazole |
| ID | Term |
|---|---|
| D053799 | 2-Pyridinylmethylsulfinylbenzimidazoles |
| D013454 | Sulfoxides |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D011725 | Pyridines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
Not provided
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