Effects of Different Strategy of Fluids Administration on Acid/Base Disorders and Inflammatory Mediators

Effects of Different Strategy of Fluids Administration on Acid/Base Disorders and Inflammatory Mediators

Aim of the study is to ascertain whether a different strategy of fluids administration can be responsible of differences in terms of acid/base disorders (Stewart approach), pro-inflammatory and inflammatory mediators. Hence two groups of patients will be treated either with not-balanced solutions (Normal Saline) or balanced solutions

Inclusion Criteria:

• Patients with diagnosis of large bowel cancer
• Age > 18 years old

Exclusion Criteria:

Emergency surgery for bowel punch or intestinal occlusion

• Massive bleeding
• Therapy with corticosteroid or nonsteroid antiinflammatory substances
• Renal insufficiency (serum creatinine > 200 micromol /l)
• Cardiac insufficiency (NYHA III-IV)
• Altered liver function (ALT > 40 U/l AST >40 U/l)
• Preoperative anaemia ( Hb < 10 g/dl )
• Allergy to hydrossietilic starches
• Patient rejection to share the study