Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of the study is to compare, in patients with acute respiratory failure/acute lung injury the efficacy of three different methods of oxygenation to prevent endotracheal intubation :
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| O2 conventional : standard low flow therapy | Active Comparator | in order to obtain a SpO2>92% |
|
| O2-HNF : high flow nasal oxygen therapy | Experimental | set between 30 to 50 l/min,adjusted in order to obtain a SpO2 >92%. |
|
| O2-HFN/NPPV | Experimental | cycling of NIV and O2-HDN |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| O2 conventional | Other | standard low flow therapy |
| |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the number of patients in each group who require endotracheal intubation with mechanical ventilation | at day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| mechanical ventilation-free to day 28 | 28 days | |
| ICU morbidity | at day 28 |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Poitiers University Hospital | Poitiers | 86021 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38783367 | Derived | Demoule A, Baptiste A, Thille AW, Similowski T, Ragot S, Prat G, Mercat A, Girault C, Carteaux G, Boulain T, Perbet S, Decavele M, Belin L, Frat JP; from the REVA Network (Research Network in Mechanical Ventilation). Dyspnea is severe and associated with a higher intubation rate in de novo acute hypoxemic respiratory failure. Crit Care. 2024 May 23;28(1):174. doi: 10.1186/s13054-024-04903-5. | |
| 25981908 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| O2-HFN : high flow nasal oxygen therapy |
| Device |
The patient will receive high flow nasal of humidified oxygen, set between 30 to 50 l/min. The inspired fraction of oxygen (FiO2) will be adjusted in order to obtain a SpO2 >92%. |
|
| O2-HFN/NPPV : association of high flow nasal oxygen therapy and non invasive positive pressure ventilation | Device | The patient will receive successively in a day NPPV and O2-HFN. The NPPV will be applied with an airway humidification achieved by using a heated humidifier and a facial mask adapted to the morphology of the patient. The settings will be adjusted as follow : an inspiratory pressure between 6 to 14 cmH2O, in order to obtain a tidal volume between 7 to 10 ml/kg of predicted weight, a positive expiratory pressure between 0 to 10 cmH2O in order to obtain a SpO2 >92% with the minimal FiO2. |
|
| Derived |
| Frat JP, Thille AW, Mercat A, Girault C, Ragot S, Perbet S, Prat G, Boulain T, Morawiec E, Cottereau A, Devaquet J, Nseir S, Razazi K, Mira JP, Argaud L, Chakarian JC, Ricard JD, Wittebole X, Chevalier S, Herbland A, Fartoukh M, Constantin JM, Tonnelier JM, Pierrot M, Mathonnet A, Beduneau G, Deletage-Metreau C, Richard JC, Brochard L, Robert R; FLORALI Study Group; REVA Network. High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med. 2015 Jun 4;372(23):2185-96. doi: 10.1056/NEJMoa1503326. Epub 2015 May 17. |
| ID | Term |
|---|---|
| D055371 | Acute Lung Injury |
| ID | Term |
|---|---|
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
Not provided
Not provided