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The use of corifollitropin alfa is superior in terms of pregnancy outcome parameters as compared to recombinant follicle stimulating hormone (FSH) during ovarian stimulation protocols in women undergoing in vitro fertilisation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| corifollitropin alfa | Experimental |
| |
| recombinant follicle stimulating hormone (FSH) | Active Comparator | 150-300 IU of FSH for ovarian stimulation in women undergoing IVF |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| corifollitropin alfa | Drug | 100 microg for a group of women weighing <or=60 kg and 150 microg for a group of women weighing >60 kg |
|
| Measure | Description | Time Frame |
|---|---|---|
| no of oocytes (>2 between groups) | at egg recovery, through study completion, an average of 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical pregnancy rate cancellation rate miscarriage rate ectopic pregnancy rate | The presence of fetal heart at transvaginal ultrasound at 6+2 gestational weeks | 3 weeks after embryo transfer |
| Ongoing pregnancy rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| 3rd Department of Obstetrics and Gynecology, Assisted Reproduction Unit | Athens | Chaidari | 12462 | Greece | ||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28508691 | Result | Siristatidis C, Dafopoulos K, Christoforidis N, Anifandis G, Pergialiotis V, Papantoniou N. Corifollitropin alfa compared with follitropin beta in GnRH-antagonist ovarian stimulation protocols in an unselected population undergoing IVF/ICSI. Gynecol Endocrinol. 2017 Dec;33(12):968-971. doi: 10.1080/09513590.2017.1323203. Epub 2017 May 16. |
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We will be happy to share the data
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| recombinant follicle stimulating hormone (FSH) | Drug | 150-300 IU of the drug daily from day 2 of the menstrual cycle until more than 2 follicles are >18mm |
|
The presence of fetal heart at ultrasound after 12 gestational weeks
| 12 weeks after embryo transfer |
| miscarriage rate | through study completion, an average of 2 years |
| live birth rate | through study completion, an average of 2 years |
| Attikon University Hospital |
| Athens |
| Chaidari |
| 12642 |
| Greece |
| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| C437186 | follicle stimulating hormone, human, with HCG C-terminal peptide |
| D015292 | Glycoprotein Hormones, alpha Subunit |
| ID | Term |
|---|---|
| D006063 | Chorionic Gonadotropin |
| D006062 | Gonadotropins |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D005640 | Follicle Stimulating Hormone |
| D006065 | Gonadotropins, Pituitary |
| D007986 | Luteinizing Hormone |
| D010908 | Pituitary Hormones, Anterior |
| D010907 | Pituitary Hormones |
| D013972 | Thyrotropin |
| D010926 | Placental Hormones |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
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