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Electroconvulsive therapy (ECT) has been shown to be an effective treatment for patients suffering from depression, who do not respond to medical treatment. However it is often dismissed by patients, who feel uncomfortably about the application of electric shocks to their heads. In 2000, magnetic seizure therapy (MST) has been introduced which uses magnetism instead of electricity to evoke convulsions. MST seems to be as effective as ECT in terms of its antidepressant potency but may be associated with less severe cognitive side effects.
Control of anaesthesia during seizure therapy is demanding since light anesthesia might be associated with awareness, whereas deep anesthesia impedes the antidepressant effect of the convulsion. Therefore, Bispectral index (BIS) monitoring is frequently used to tailor anaesthesia for ECT, however little is known about BIS following MST.
The investigators hypothesize that in comparing MST with ECT, (a) patients show a faster increase in BIS and that (b)less left-right differences occur in BIS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Magnetic Seizure Therapy Group | Patients receiving magnetic seizure therapy for depression | ||
| Electroconvulsive Therapy Group | Patients receiving electroconvulsive therapy for depression |
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| Measure | Description | Time Frame |
|---|---|---|
| Recovery Time | recovery time from seizure induction to eye opening / restoration of breathing | same day |
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Inclusion Criteria:
Exclusion Criteria:
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Patients suffering from depression
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| Name | Affiliation | Role |
|---|---|---|
| Martin Soehle, MD, PhD | Dept of Anaesthesiology and Intensive Care Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Anaesthesiology and Intensive Care Medicine & Dept. of Psychiatry and Psychotherapy, University of Bonn Hospital | Bonn | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24305645 | Result | Soehle M, Kayser S, Ellerkmann RK, Schlaepfer TE. Bilateral bispectral index monitoring during and after electroconvulsive therapy compared with magnetic seizure therapy for treatment-resistant depression. Br J Anaesth. 2014 Apr;112(4):695-702. doi: 10.1093/bja/aet410. Epub 2013 Dec 3. | |
| 34131914 | Derived | Jiang J, Zhang C, Li C, Chen Z, Cao X, Wang H, Li W, Wang J. Magnetic seizure therapy for treatment-resistant depression. Cochrane Database Syst Rev. 2021 Jun 16;6(6):CD013528. doi: 10.1002/14651858.CD013528.pub2. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Magnetic Seizure Therapy Group | Patients receiving magnetic seizure therapy for depression completed |
| FG001 | Electroconvulsive Therapy Group | Patients receiving electroconvulsive therapy for depression |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Magnetic Seizure Therapy Group | Patients receiving magnetic seizure therapy for depression |
| BG001 | Electroconvulsive Therapy Group | Patients receiving electroconvulsive therapy for depression |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Recovery Time | recovery time from seizure induction to eye opening / restoration of breathing | Posted | Mean | Standard Deviation | minutes | same day |
|
|
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Magnetic Seizure Therapy Group | Patients receiving magnetic seizure therapy for depression: None |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Prof. Dr.Martin Soehle | Dept. of Anesthesiology and Intensive Care Medicine | ++49-228-287- | 11378 | martin.soehle@ukb.uni-bonn.de |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| Participants |
|
|
| 0 |
| 10 |
| 0 |
| 10 |
| EG001 | Electroconvulsive Therapy Group | Patients receiving electroconvulsive therapy for depression: None | 0 | 10 | 0 | 10 |
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