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The aim of this study is to investigate the incidence and possible causes of obscured or disrupted cone outer segment tips line at fovea in spectral-domain optical coherence tomography images of normal eyes.
Thirty-seven eyes of 37 individuals without eye diseases were included in this study. Optical Coherence Tomography (OCT) images were taken using Cirrus HD-OCT (Carl Zeiss Meditec) with 5 line raster and high-definition 5 line raster modes. Images with signal strength weaker than 5/10 were excluded. Distinction of COST line and the integrity of COST line, external limiting membrane, and the photoreceptor inner segment and outer segment junction at the fovea were recorded. Demographic data, refractive error of the eyes, signal strengths of the OCT images were acquired for analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal subjects | Thirty-seven eyes of 37 individuals without eye diseases |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Optical coherence tomography | Other | Optical coherence tomography |
|
| Measure | Description | Time Frame |
|---|---|---|
| Microstructural analysis by Spectral domain optical coherence tomography | SD-OCT images of 6 mm scans were taken using Cirrus HD-OCT (OCT 4000, Carl Zeiss Meditec, Dublin, CA) with 5 line raster (5LR) and high-definition 5 line raster (HD5LR) modes. | one year |
| Measure | Description | Time Frame |
|---|---|---|
| Visual acuity | Each subject had a routine eye examination including measuring best-corrected visual acuity (BCVA) and intraocular pressure. | one year |
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Inclusion Criteria:
Exclusion Criteria:
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Thirty-seven eyes of 37 individuals without eye diseases
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| Name | Affiliation | Role |
|---|---|---|
| Makoto Inoue, MD | Kyorin Eye Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kyorin Eye Center | Mitaka | Tokyo | 181-8611 | Japan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22018706 | Derived | Rii T, Itoh Y, Inoue M, Hirakata A. Foveal cone outer segment tips line and disruption artifacts in spectral-domain optical coherence tomographic images of normal eyes. Am J Ophthalmol. 2012 Mar;153(3):524-529.e1. doi: 10.1016/j.ajo.2011.08.021. Epub 2011 Oct 21. |
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| ID | Term |
|---|---|
| D041623 | Tomography, Optical Coherence |
| ID | Term |
|---|---|
| D041622 | Tomography, Optical |
| D061848 | Optical Imaging |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
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| D003933 | Diagnosis |
| D014054 | Tomography |
| D008919 | Investigative Techniques |