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The purpose of the protocol is to determine typical patient response to Dysport in the treatment of adult cervical dystonia (CD).
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| Measure | Description | Time Frame |
|---|---|---|
| Proportion of treatment responders using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) severity scale score | Cycle 1 - Baseline and week 4 | |
| Patient Global Impression of Change using the 7-point Likert scale | Cycle 1 - Baseline and week 4 |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Global Impression of Change using the 7-point Likert scale | Cycle 1 - Week 4 and early termination visit | |
| Patient Global Impression of Change using the 7-point Likert scale | Cycle 1 - Week 4; Cycles 2 to 4 - Baseline, week 4 and termination visits |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients with Cervical Dystonia treated with Dysport
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| Name | Affiliation | Role |
|---|---|---|
| Ipsen Study Director | Ipsen | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Arizona Dystonia Institute | Scottsdale | Arizona | 85258 | United States | ||
| East Bay Physicians Medical Group |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34316644 | Derived | Trosch RM, Misra VP, Maisonobe P, Om S. Impact of abobotulinumtoxinA on the clinical features of cervical dystonia in routine practice. Clin Park Relat Disord. 2020 Jun 15;3:100063. doi: 10.1016/j.prdoa.2020.100063. eCollection 2020. | |
| 29530726 | Derived | Espay AJ, Trosch R, Suarez G, Johnson J, Marchese D, Comella C. Minimal clinically important change in the Toronto Western Spasmodic Torticollis Rating Scale. Parkinsonism Relat Disord. 2018 Jul;52:94-97. doi: 10.1016/j.parkreldis.2018.03.002. Epub 2018 Mar 7. |
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| Time to Waning Effect of Dysport treatment/symptom re-emergence | Cycles 1 to 4 - Week 8 and at study termination visits |
| Patient-self-administered questionnaire (Cervical Dystonia Impact Profile-58) | Cycles 1 & 3: Baseline |
| Patient-reported assessment of pain using the Pain Numeric Rating Scale (NRS) | Cycles 1 to 4 - Baseline, week 4 and at study termination visits |
| Treatment Satisfaction Questionnaire for Medication (TSQM) | Cycle 1 - Week 4; Cycles 2 to 4 - Baseline, week 4 and termination visit |
| Berkeley |
| California |
| 94705 |
| United States |
| Headache Center | Encinitas | California | 92024 | United States |
| The Parkinson's & Movement Disorder Institute | Fountain Valley | California | 92708 | United States |
| Neuro-Pain Medical Center | Fresno | California | 93710 | United States |
| Coastal Neurological Medical Group, Inc. | La Jolla | California | 92037 | United States |
| Valley Parkinson Clinic | Los Gatos | California | 95032 | United States |
| Harvinder S. Birk | Redding | California | 96001 | United States |
| Colorado Springs Neurological Associates | Colorado Springs | Colorado | 80907 | United States |
| University of Colorado Denver | Denver | Colorado | 80045 | United States |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | United States |
| Neurology Offices of South Florida | Boca Raton | Florida | 33428 | United States |
| Parkinson's Disease and Movement Disorders Center of Boca Raton | Boca Raton | Florida | 33486 | United States |
| Infinity Clinical Research, LLC | Hollywood | Florida | 33021 | United States |
| University of Miami, Dept. of Movement Disorders Clinic | Miami | Florida | 33136 | United States |
| Palm Beach Gardens Medical Center | North Palm Beach | Florida | 33408 | United States |
| Emerald Coast Center for Neurological Disorders | Pensacola | Florida | 32514 | United States |
| Parkinson's Treatment Center of SW Florida | Port Charlotte | Florida | 33980 | United States |
| USF HealthParkinson's Disease and Movement Disorders Center | Tampa | Florida | 33613 | United States |
| Cleveland Clinic Florida | Weston | Florida | 33331 | United States |
| Elks Rehab Hospital - Movement Disorders Center | Boise | Idaho | 83702 | United States |
| Rush University Medical Center Department of Neurological Sciences | Chicago | Illinois | 60612 | United States |
| Kansas City Bone & Joint Clinic, PA Overland Park | Overland Park | Kansas | 66211 | United States |
| Baptist Neurology Center - Lexington | Lexington | Kentucky | 40503 | United States |
| The Neuro Medical Center | Baton Rouge | Louisiana | 70810 | United States |
| The Parkinson's and Movement Disorders Center | Southfield | Michigan | 48034 | United States |
| Rehabilitation Consultants, PA | Eagan | Minnesota | 55121 | United States |
| Methodist Rehabilitation Center | Jackson | Mississippi | 39216 | United States |
| University of Nevada School of Medicine | Reno | Nevada | 89502 | United States |
| Empire Neurology PC, the MS Center of Northeastern New York | Latham | New York | 12110 | United States |
| Raleigh Neurology Associates | Raleigh | North Carolina | 27607 | United States |
| Riverhills Neuroscience | Cincinnati | Ohio | 45219 | United States |
| University Neurology, Inc. | Cincinnati | Ohio | 45267 | United States |
| Cleveland Clinic Center for Neurological Restoration | Cleveland | Ohio | 44195 | United States |
| Capital Neurology Services & MS Institute | Gahanna | Ohio | 43230 | United States |
| Neurological Associates of Tulsa | Tulsa | Oklahoma | 74137 | United States |
| Columbia Pain Management, PC | Hood River | Oregon | 97031 | United States |
| Allegheny General Hospital_Department of Neurology | Pittsburgh | Pennsylvania | 15212 | United States |
| Coastal Neurology, PA | Port Royal | South Carolina | 29935 | United States |
| Victorium Clinical Research | San Antonio | Texas | 78229 | United States |
| Neurology Center of San Antonio | San Antonio | Texas | 78258 | United States |
| Gershon Pain Specialists | Virginia Beach | Virginia | 23454 | United States |
| Evergreen Hospital Medical Center/Booth Gardner Parkinson's Care Center | Kirkland | Washington | 98034 | United States |
| South Puget Sound Neurology | Tacoma | Washington | 98405 | United States |
| Gundersen Clinic, Ltd. | La Crosse | Wisconsin | 54601 | United States |
| ID | Term |
|---|---|
| D014103 | Torticollis |
| ID | Term |
|---|---|
| D004421 | Dystonia |
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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