The purpose of this study is to determine whether a polipill improved the compliance with treatment compared to usual care that use two or more drugs,in patients at high cardiovascular risk or previous cardiovascular disease.

Inclusion Criteria:

• Adults age ≥ 18 years old;
• Patient that could written informed consent;
• Patient with current atherothrombotic cardiovascular disease or at high cardiovascular risk, defined as:
• Patients with previous Coronary Artery Disease (miocardial Infarction, estable or instable angina pectoris or coronary revascularization procedures);
• Patients with previous miocardial Infarction, defined as medical registry (with documentation of at least 2 criterias: clinical symptoms,patological electrocardiogram and elevation of cardiac enzymes- CK-MB and/or troponin);
• Patients with previous brain ischemia (stroke or transient ischemic attack)
• Patients with confirmed previous peripheral arterial disease (Coronary Artery Bypass procedures or angioplasty or amputation due peripheral arterial disease)
• Patients with no established cardiovascular disease but at high cardiovascular risk, defined as 15% or more in 5 years (using the Anderson Framingham scale, 1991)

Exclusion Criteria:

• contraindication for any of the polipill
• If the physician opinion is that terapeutical change could harm the patient (for example, heart failure, need of high beta blocker dose for treatment angina symptons and for the atrial fibrillation rhythm,severe hypertension [degree 3], malignant hypertension or renal insufficiency
• Acute clinical conditions/ surgeries
• Psychiatry clinical conditions(for example, schizophrenia, serious depression)
• pregnant or lactation women
• women at fertile period mulheres not using effective contraceptive methods (oral contraceptive, condom, intrauterine device)
• liver siseases (AST/ALT/FA upon 3 x normal superior limits / bilirrubin upon 1,5 X normal superior limits / diagnosed Liver Cirrhosis
• Renal disfunction (any laboratorial exams upon 3 x normal superior limits)
• Previous participation on other clinical trial
• The participant is unable or refuse to give informed consent.