Safety and Intraocular Pressure (IOP) Lowering Effect of AL-59412C

A Proof of Concept Study to Assess the Safety and IOP-Lowering Effect of AL-59412C Injected Intravitreally

The purpose of this study was to assess the safety and efficacy of AL-59412C injected intravitreally relative to Vehicle.

Inclusion Criteria:

• Diagnosis of primary open-angle glaucoma or ocular hypertension.
• Retinal pathology (eg, retinal degeneration), anterior ischemic optic neuropathy, or vascular occlusion resulting in poor vision in the study eye.
• Able to discontinue all intraocular-lowering (IOP) medications according to the minimum washout period, based upon the class of medication.
• Mean washed out IOP ≥ 24 millimeters mercury (mmHg) to ≤ 36 mmHg at 8 AM in the study eye on two separate Eligibility Visits.
• Other protocol-defined inclusion criteria may apply.

Exclusion Criteria:

• Lens/corneal/vitreal opacity preventing adequate posterior segment visualization of the study eye.
• Current or recent (within 30 days) use of any drug that may prolong the QT interval.
• Poor vision resulting from advanced glaucoma in the study eye.
• Intraocular surgery within the past 6 months in the study eye.
• Ocular laser surgery within the past 3 months in the study eye.
• Other protocol-defined exclusion criteria may apply.