Neoadjuvant Chemotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN)

Concurrent Chemoradiation Versus Induction Docetaxel, Cisplatin and 5-fluorouracil (TPF) Followed by Concomitant Chemoradiotherapy in Locally Advanced Hypopharyngeal and Base of Tongue Cancer: A Randomized Phase II Study

The investigators will examine whether 2-cycles of DFP chemotherapy before definitive concurrent chemoradiation therapy (CCRT) can improve progression-free survival in locally advanced (Stage III & IVM0) hypopharyngeal and base of tongue carcinoma compared to definitive CCRT alone.

Inclusion Criteria:

• Histologically/cytologically proven stage III/IVM0 hypopharyngeal or base of tongue cancer
• One or more evaluable or measurable lesion
• No prior chemotherapy, radiation, or surgery
• ECOG 0-2

Exclusion Criteria:

• Distant metastasis
• Other malignancy