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| ID | Type | Description | Link |
|---|---|---|---|
| Copenhagen study 2011:1 | Other Grant/Funding Number | Region Skane, SWEDEN |
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Hypothesis: General anesthesia as compared to intrathecal (i.e. spinal anesthesia) anesthesia will result in shorter length of hospital stay for patients undergoing total knee arthroplasty.
Primary endpoint: time from end of surgery until the patient is "street ready"
Secondary endpoints: will general anesthesia produce less postoperative pain as compared to intrathecal anesthesia? Is there any difference in post operative "dizziness" between the groups.
Hypothesis: General anaesthesia compared to intrathecal anaesthesia will give shorter length of hospital stay (LOS) for patients undergoing total knee arthroplasty (TKA).
Primary endpoint: time from end of surgery until the patient meets the discharge criteria.
Secondary endpoints:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| General Anesthesia | Experimental | Patients allocated to this arm will receive general anesthesia using propofol 10 mg/ml and remifentanil 50 ug/ml in a Target Controlled Infusion (TCI) |
|
| Regional anesthesia | Active Comparator | Patients will receive intrathecal anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| General anesthesia | Procedure | Patients will receive general anesthesia using propofol 10 mg/ml and remifentanil 50 ug/ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| time from end of surgery until patient is "street ready" | Time from end of surgery until the patient is street ready will be monitored. If the patient is street ready will be evaluated twice daily each day after the surgery. | within 4 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Will general anesthesia produce less post operative pain as compared to intrathecal? | Pain will be measured using a visual analogue scale. The patient's own evaluation (questionnaires about quality of life and knee function)
|
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sören Toksvig-Larsen, M.D. PhD | Dept Ortopedic surgery, Hässleholm Hospital, SWEDEN | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept orthopedic surgery at Hässleholm hospital | Hässlehom | 28125 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18211990 | Background | Fowler SJ, Symons J, Sabato S, Myles PS. Epidural analgesia compared with peripheral nerve blockade after major knee surgery: a systematic review and meta-analysis of randomized trials. Br J Anaesth. 2008 Feb;100(2):154-64. doi: 10.1093/bja/aem373. | |
| 9009936 | Background | Minto CF, Schnider TW, Shafer SL. Pharmacokinetics and pharmacodynamics of remifentanil. II. Model application. Anesthesiology. 1997 Jan;86(1):24-33. doi: 10.1097/00000542-199701000-00005. |
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| ID | Term |
|---|---|
| D001168 | Arthritis |
| ID | Term |
|---|---|
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| D000768 | Anesthesia, General |
| D013390 | Succinylcholine |
| D000388 | Air |
| D000765 | Anesthesia, Conduction |
| ID | Term |
|---|---|
| D000758 | Anesthesia |
| D000760 | Anesthesia and Analgesia |
| D002794 | Choline |
| D050337 | Trimethyl Ammonium Compounds |
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| Regional anesthesia | Procedure | Patients will receive intrathecal anesthesia |
|
|
| 48 hrs after surgery |
| 19025523 | Background | Andersen LO, Husted H, Otte KS, Kristensen BB, Kehlet H. High-volume infiltration analgesia in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. Acta Anaesthesiol Scand. 2008 Nov;52(10):1331-5. doi: 10.1111/j.1399-6576.2008.01777.x. |
| D000644 |
| Quaternary Ammonium Compounds |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D013386 | Succinates |
| D003998 | Dicarboxylic Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D009861 | Onium Compounds |
| D001272 | Atmosphere |
| D004777 | Environment |
| D055669 | Ecological and Environmental Phenomena |
| D001686 | Biological Phenomena |
| D008685 | Meteorological Concepts |
| D004778 | Environment and Public Health |