Visceral Stiffness Measurement Using Acoustic Radiation Force Impulse

Clinical Application of the Spectrum of Visceral Stiffness Measurement Using Acoustic Radiation Force Impulse Technology

The acoustic radiation force impulse (ARFI) technology provides real-time measurements of tissue stiffness.

Aim: Using the ARFI ultrasonography, the investigators aims are to complete the correlation and validity studies between visceral ARFI quantification and the referenced Metavir fibrosis scoring and to conduct subsequent innovative studies on liver diseases.

Using ARFI technology, we are establishing a complete hepatic and visceral shear wave spectrum to correspond to the entire METAVIR fibrosis scoring and various functional stratifications.

Inclusion Criteria:

• patients with chronic liver diseases who underwent liver biopsy
• patients with pathologically or radiologically proven cirrhosis

Exclusion Criteria:

• Post major abdominal surgery
• After interferon or neucleos(t)ides treatment
• PBC,PSC,WD,AIH,viral coinfections
• Liver abscess
• Exposure to hepatotoxic drugs or chemicals
• Thrombosis of splenic vein, portal veins
• After resection or embolism of the spleen
• Acute or chronic pancreatitis
• Biopsy contraindications (not exclusive)
• ARFI measurements low quality
• Fibrotest contraindications:

Acute hepatitides, Extrahepatic cholestasis, e.g., pancreatic cancer, gallstones, CBD>0.7cm Severe hemolysis

• Cardiac congestion
• Liver cancer other than HCC
• Treated HCC