In some studies once daily amoxicillin therapy might be treatment of choice for Group A β-hemolytic Streptococcus pharyngitis in comparison with three to four times daily treatment with oral penicillin V.

Inclusion Criteria:

Inclusion Criteria:

1. Age of 6 to 15 years old.
2. The criteria in clinical examination including objective signs (fever, Erythema or exudate of tonsils, enlarged lymph nodes) and subjective sign(sore throat). Neck tenderness, abdominal pain and pharynx petechia were also considered.
3. No antibiotic was used during the week before.
4. -Performing throat culture before the initiation of drug administration
5. Positive throat culture indication GABHS
6. No previous history of allergy to penicillin .

Exclusion Criteria:

1. Age of below 6 years old or above 15 years old.
2. No signs of pharyngitis in the clinical examination
3. Antibiotic use during the week before.
4. Throat culture was not performed before the initiation of drug administration.
5. Negative throat culture or the culture indicates a microorganism other than GABHS.
6. History of allergy to penicillin
7. Not using drugs or not following the treatment in the field of having the second culture performed.