A study in healthy subjects and mild asthmatics to investigate Pharmacokinetics of AZD5423 when administered in different ways.

Inclusion Criteria:

• Male healthy subjects and male asthma patients aged 18 to 45 years (inclusive)
• Have a body mass index (BMI) between 18 and 30 kg/m2 (inclusive and rounding allowed) and weight between 50 and 100 kg (inclusive)
• Be able to inhale from the SPIRA nebuliser and I-neb® according to the provided instructions
• Asthma patients should fulfil the following criteria: Pre-bronchodilator forced expiratory volume at 1 second (FEV1) ≥70% of predicted normal value
• Asthma diagnosis according to GINA guidelines with a history of episodic wheeze and shortness of breath

Exclusion Criteria:

• History of any clinically significant disease or disorder
• Any clinically relevant abnormal findings
• Current smokers
• Asthma patients: Worsening of asthma or respiratory infection within 6 weeks before screening
• Asthma patients: Use of inhaled, nasal, oral, rectal or parenteral corticosteroids within 30 days before first administration of investigational product and during the study