Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With Sertraline

Does Pregabalin Improve Symptoms of Anxiety in Patients With Epilepsy? A Comparison With Sertraline

The aim of the study is to compare the safety & efficacy of sertraline (up to a dose of 200mg/day) & pregabalin (up to a dose of 300mg/day) for the treatment of symptoms of anxiety in patients with epilepsy.

Patients with epilepsy will be treated with either sertraline (up to a dose of 200mg/day) or pregabalin (up to a dose of 300mg/day) for the treatment of symptoms of anxiety. Outcome measures will include changes in the anxiety severity scales.

Inclusion Criteria:

• GAD-7 total score above 10.
• Have a diagnosis of a Partial Seizure Disorder.
• Have a Hamilton-A total score 20 and above.
• 18-80 years of age.
• Able to read at a fourth grade level.
• If a woman of childbearing age, agrees to use an acceptable means of birth control.

Exclusion Criteria:

• Unable to understand and sign a consent.
• Unable to follow instructions for the study.
• Displaying current suicidal ideation
• Having psychogenic non-epileptic seizures
• Have a history of drug or alcohol abuse.
• Use of any investigational drug within the last 30 days.
• Hypersensitivity reaction or other serious adverse event to PGB in prior trials.