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| Name | Class |
|---|---|
| Fundación Mundo Sano | UNKNOWN |
| Albert B. Sabin Vaccine Institute | OTHER |
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The general purpose of the project is to analyse soil-transmitted helminthiases (STH) in a highly endemic area in northern Argentina with a multidisciplinary approach. The specific objectives are to evaluate the local epidemiology of STH, validate a new diagnostic serology method for S. stercoralis and evaluate the efficacy and safety of a mass drug administration regimen with albendazole and ivermectin.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ivermectin + Albendazole | Drug | Ivermectin: 200µg/kg, single dose, PO + Albendazole 200 (children between 12 and 23 months) or 400 mg (>= 2 years old) single dose, PO |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of local epidemiology of soil-transmitted helminthiases and impact of a mass drug treatment anti-helminthic strategy | Evaluate local epidemiology of STH: frequency of species, prevalence and intensity of infections, groups more affected, morbidity. Evaluate the efficacy of a single-dose anti-helminthic regimen for community treatments: albendazole 400 mg + ivermectin 200 mcg/kg. | 15 months |
| Measure | Description | Time Frame |
|---|---|---|
| Validate serology methods for diagnosis of S. stercoralis infection | Compare sensibility, specificity and predictive values of serology for S.stercoralis (ELISA-NIE) with traditional coproparasitological methods | 15 months |
| Assess the tolerability and safety of the combination of ivermectin and albendazole |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alejandro Krolewiecki, MD, PhD | Contact | +54-11-45531369 | alekrol@hotmail.com | |
| MarÃa E SocÃas, MD | Contact | +54-11-4803-2298 | eugenia_socias@yahoo.com.ar |
| Name | Affiliation | Role |
|---|---|---|
| Alejandro Krolewiecki, MD, PhD | Universidad Nacional de Salta, Instituto de Investigación en Enfermedades Tropicales | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto de Investigación en Enfermedades Tropicales, Universidad Nacional de Salta | Recruiting | Orán | Salta Province | 4530 | Argentina |
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| ID | Term |
|---|---|
| D006373 | Helminthiasis |
| ID | Term |
|---|---|
| D010272 | Parasitic Diseases |
| D007239 | Infections |
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| ID | Term |
|---|---|
| D007559 | Ivermectin |
| D015766 | Albendazole |
| ID | Term |
|---|---|
| D018942 | Macrolides |
| D061065 | Polyketides |
| D007783 | Lactones |
| D009930 | Organic Chemicals |
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| 15 months |
| D002219 |
| Carbamates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D001562 | Benzimidazoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |