Myocardial Physiology And Microanatomy In Individuals Undergoing Heart Surgery

Study of Gaining Further Understanding of the Underlying Mechanisms of Myocardial Function

The main focus of the project is to determine to what degree myocardial energy metabolism is linked to impaired function in human cardiomyocytes, whether exercise training and remote ischemic preconditioning can restore cardiomyocyte function and whether this is linked to improved mitochondrial and cell function.

Inclusion Criteria:

• Patients undergoing coronary heart surgery and heart transplantation

Exclusion Criteria:

• myocardial infarction closer than 4 weeks to project start, serious valve defects, diabetes, unstable angina, uncontrolled hypertension, kidney failure (creatinin > 140)