Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Chulalongkorn University | OTHER |
| Queen Sirikit National Institute of Child Health | OTHER_GOV |
| Srinagarind Hospital, Khon Kaen University | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
To compare the safety and efficacy of low-dose versus standard dose lopinavir/ritonavir containing HAART regimen in virological suppress, HIV RNA viral load < 50 copies/ml at 48 week
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| standard dose | Active Comparator | Arm 1:LPV/r Standard dose BW 25-35 kg 300/75 mg BW >35-50 kg 400/100 mg |
|
| low dose | Experimental | Arm 2:Low dose BW 25-35 kg 200/50 mg BW >35-50 kg 300/75 mg |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| kaletra | Drug | The study participants will receive Lopinavir/ritonavir heat-stable tablet (100/25 mg or 200/50 mg) q 12 hour plus NRTIs. The other NRTIs is depend on physician discretion. Arm 1:LPV/r Standard dose Arm 2:Low dose BW 25-35 kg 300/75 mg 200/50 mg BW >35-50 kg 400/100 mg 300/75 mg |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the safety and efficacy of low-dose versus standard dose lopinavir/ritonavir containing HAART regimen in virological suppress, HIV RNA viral load < 50 copies/ml at 48 week | proportion of patient who had HIV RNA < 50 copies/ml Safety issue: patient who had HIV RNA > 50 copies/ml during the study period will be checked for LPV blood level, if the LPV Cmin < 1 ug/ml. The dose of LPV/r will be adjusted to appropriate dose. | 48 week |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Thanyawee Puthanakit, MD | Department of Pediatric , Faculty of Medicine, Chulalongkorn University and Thai Red Cross AIDS Research Centre - HIV-NAT | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Srinagarind Hospital, Khon Kaen University | Khon Kaen | Changwat Khon Kaen | Thailand | |||
| Bamrasnaradura Institute |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| Result | A randomized study comparing low dose versus standard dose lopinavir/ritonavir among HIV-infected children with virological suppression . Presented at 7th IAS 2013 in June 30-July 3, 2013 in Kuala Lumpur, Malaysia as abstract presentation. | ||
| Result | Association of SCLO1B1 polymorphism and plasma concentration of lopinavir in HIV-infected children. Presented at 7th IAS 2013 in June 30-July 3, 2013 in Kuala Lumpur, Malaysia as abstract presentation and 5th International Workshop on HIV Pediatrics in June 28-29, 2013 in Kuala Lumpur, Malaysia |
| Label | URL |
|---|---|
| HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT) | View source |
Not provided
Not provided
| Bamrasnaradura Infectious Diseases Institute |
| OTHER_GOV |
| Nakornping Hospital | OTHER |
| Prapokklao Hospital | UNKNOWN |
| Surin Hospital | UNKNOWN |
| Sappasitthiprasong Hospital | UNKNOWN |
| UdonThani Hospital | OTHER_GOV |
| Buddhachinaraj Hospital | OTHER |
| Phrachomklao Hospital | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Nonthaburi |
| Changwat Nonthaburi |
| 11000 |
| Thailand |
| Queen Sirikit National Institute of Child Health | Bangkok | Thailand |
| Prapokklao Hospital | Chanthaburi | Thailand |
| Nakornping Hospital | Chiang Mai | Thailand |
| Phrachomklao Hospital | Phetchaburi | Thailand |
| Buddhachinaraj Hospital | Phitsanulok | Thailand |
| Surin Hospital | Surin | Thailand |
| Sappasitthiprasong Hospital | Ubonratchathani | Thailand |
| Udonthani Hospital | Udon Thani | Thailand |
| ID | Term |
|---|---|
| C558899 | lopinavir-ritonavir drug combination |
Not provided
Not provided
Not provided