Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Resection

Effect of Remote Ischemic Preconditioning on Lung Injury in Patients Undergoing Pulmonary Resection:a Randomised Controlled Trial

The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary resection.

Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary resection, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.

Inclusion Criteria:

• Clinical diagnosis of pulmonary carcinoma
• Must be received pulmonary lobectomy

Exclusion Criteria:

• Cardiac disease categorized as NYHA classes II-IV
• Preoperative severe impairment of respiratory function (arterial oxygen tension (PaO2) <60 mmHg or FEV1<50% predicted),
• Pre-existing coagulopathy or thrombocytopenia
• Prior receipt of chemotherapy or radiation therapy or immunotherapy
• Systemic or local active infections (either clinically defined or suggested by evidence such as elevated C-reactive protein levels, leukocytosis, or a body temperature>38℃)
• Peripheral vascular disease affecting the upper limbs
• Administration of vitamins, nonsteroidal anti-inflammatory agent or corticosteroid within 3 months.