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| ID | Type | Description | Link |
|---|---|---|---|
| hydration-1 | Other Identifier | Cosmos Technical Center |
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| Name | Class |
|---|---|
| University of Dundee | OTHER |
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The effects of topically applied pyridoxine tri-isopalmitate (P-IP) which stimulates filaggrin synthesis in keratinocytes, on skin hydration and barrier function were examined. Subjects were separated into two groups to examine the effect of P-IP. Subjects were treated with P-IP formulation on one side of the face and with a placebo formulation on the other side twice daily (morning and evening) for 28 days. All subjects gave written informed consent prior to the study. The skin hydration and TEWL (transepidermal water loss) were evaluated by measuring skin surface conductance with a skin hygrometer SKICON 200EX (I.B.S. ltd., Japan) and TEWL meter AS-CT1 (ASAHI BIOMED, Tokyo, Japan), respectively.
It is expected that the long-term application of P-IP increase skin surface water contents and suppress TEWL.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Evaluation of P-IP on hydration and barrier function | Experimental | Effects of P-IP on improvement of skin hydration and TEWL were examined. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pyridoxine tri-isopalmitate | Other | 2% dosage, oil-in-water emulsion, twice a day, 28 days |
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| Measure | Description | Time Frame |
|---|---|---|
| Measurement of skin surface water content and Trans-Epidermal Water Loss (TEWL) | Subjects were treated with P-IP formulation on one side of the face and with a placebo formulation (without P-IP, oil-in-water emulsion type) on the other side twice daily (morning and evening) for 28 days. Skin surface water contents and TEWLs were measured at the time frame described above and the results were analyzed as a change from a value of before-application at each measurement. | Before application, 1 week, 2 week and 4 weeks after application |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cosmos Technical Center | Itabashi-ku | Tokyo | 174-0046 | Japan |
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